N-杂环卡宾(NHC)-过渡金属络合物作为催化剂在有机合成中的应用越来越广泛，另外，鉴于不对称偶联反应研究是一个富有希望和挑战性的研究领域之一。因此，本研究项目围绕手性氮杂环卡宾(NHC)-过渡金属络合物催化不对称偶联反应展开研究工作，重点研究催化剂的效率和对映选择性问题。首先，设计、合成三个系列的手性氮杂环卡宾(NHC)-过渡金属络合物催化剂。其次，依据手性NHC配体-催化金属离子-底物三者之间的匹配关系，发展一些分子间或者分子内的不对称偶联反应体系，并合成一些具有单一或多立体手性中心的碳环、杂环、轴手性结构的光学活性化合物以及一些手性药物活性中间体等。最后，运用现代波谱分析手段和动力学实验，揭示手性催化过程中手性传递、手性诱导和不对称放大的科学规律。并结合量子化学理论计算，推导出研究反应的中间体和过渡态，并进一步理解此类不对称偶联反应机理。

N-Heterocyclic carbenes (NHC)-transition metal complexes as the catalysts have been extensively employed into organic synthesis. In addition, asymmetric coupling reaction is one of promising and challenging research area. Therefore, this research project is related to some asymmetric coupling reactions catalyzed by chiral N-heterocyclic carbene (NHC)-transition metal catalysts, and the key point focuses on the issues of catalytic efficiency and enantioselectivity of asymmetric coupling reaction. Firstly, three types of N-heterocyclic carbene (NHC)-transition metal complexes as the catalysts will be designed and synthesized in this research project. Secondly, some intermolecular and intramolecular asymmetric coupling reactions will be carefully selected and developed according to the matching relationship between the chiral NHC ligands, the catalytic metal ions and the substrates. The optically avtive single or multistereogenic carbocyclic, heterocyclic compounds, axial chiral compounds as well as some chiral pharmacologically active intermediates, will be synthesized and obtained in enantioenriched form. Finally, based on the data of modern spectroscopic analysis and kinetic experiments, the scientific nature of chiral transmission, chiral induction and asymmetric amplification will be explored and understood in this research project. Furthermore, quantum theoretical calculation will be used to locate the corresponding intermediates and transition states, and to clear their reaction mechanisms.