本研究计划将通过调控有机配体的尺寸和结构以及无机离子配位喜好定向设计合成新型的具有预想尺寸孔穴的纳米尺度的NMOFs，并筛选出生物无毒或低毒的并在生理条件下稳定的NMOFs。此外，通过后修饰方法对所合成的纳米尺度的NMOFs进行功能定向修饰，并初步探索其在与生物体生理和病理密切相关的物种如pH、硫醇、金属离子或活性氧的检测和成像分析；此外，研究MOFs多孔材料的靶向药物传输功能。在此基础上探索NMOFs的生物成像、药物传输及治疗的功能集成。该研究将有效地拓展微纳尺度的多孔MOFs的应用范围，为NMOFs化学增添新的内容。

This research project is to synthesize and characterize of nano-sized metal-organic frameworks (NMOFs) based on the geometry and length of organic ligands and coordination preference of the metal cations. After that, the stable (under physiological conditions) and safe (noncytotoxicity) NMOFs will be screened. In addition, the screened NMOFs will be modified by organic functional groups transformation to be NMOFs-based sensor via post-synthetic approach for detecting physiologically relevant species, such as pH, metal ions, RSH and intracellular reactive oxygen species (ROS). On the other hand, such NMOFs will be an ideal class of molecular containers to uptake and deliver drugs for chemotherapeutics. Based above studies, the integration of bioimaging and chemotherapeutics on the NMOFs will be explored. The research herein would effectively enlarges the application range of NMOFs in sensing and chemotherapeutics.