本研究计划将通过调控有机配体的尺寸和结构以及无机离子配位喜好定向设计合成新型的具有预想尺寸孔穴的微纳尺度的MOFs和其在基体上的有序组装，探索其器件化(如微萃取和色谱固定相)的制备及在吸附、分离检测方面的应用；针对不同的客体底物，通过改变其有机配体上的官能团或其后修饰衍生化合成主-客体适配的内腔表面，进而实现对特定底物的选择性吸附、富集和分离检测；在此基础上，通过色谱、质谱、荧光光谱等手段对其吸附、富集和分离的效率进行表征，筛选有实际应用前景的选择性吸附、富集和分离的微纳尺度MOFs材料。不仅如此，我们还将对新的多孔MOFs进行结构和形貌表征，对其不同形貌的形成机理和其吸附富集、分离的机理进行初步探讨。该研究将为微纳尺度的多孔MOFs合成方法学、器件化及在分离检测方面的应用研究提供新途径。

This research project will focus on design and synthesis of micro-nano sized porous metal-organic frameworks (MOFs) with functionalized interior cavity surface based on heterocycle or acyclic crown ether bridging organic ligands and metal ions.Moreover,the self-assembly and compositing of porous MOFs on matrix, such as filming and immobilizing on some certain substartes, will be explored. Furthermore, the adsorption, separation and detection for some target chemical species will be investigated and the potential micro-nano MOFs analytical materials will be screened. In addition, the formation mechanism of micro-nano with different morphology and the selective adsorption and separation mechanism will be studied. The corresponding results would provide an alternative approach for the preparation of micro-nano sized MOFs and corresponding detection devices.