多手性中心、多官能团化六元含氮杂环结构单元广泛存在与天然产物及药物分子中，同时也是非常重要的有机合成中间体。本项目主要研究azomethine ylide在手性金属路易斯酸催化下与一系列潜在的6-∏类型的底物发生新型不对称[6＋3]环加成反应的可能性，致力于发展构建六元含氮杂环化合物的方法学与高效的催化体系；进而深入研究反应的催化机理与过渡态，探索并总结手性催化剂中的各种因素对催化活性和反应的立体选择性的影响，揭示其与催化反应中的化学选择性、区域选择性和立体选择性的内在联系，为设计合成新的手性催化剂和开发一些新型的催化反应提供实验与理论依据。

Highly substituted six-membered nitrogen heterocycles bearing multiple stereogenic centers are prevalent scaffolds that serve as the core structures of natural alkaloids, active pharmaceutical ingredients and also useful building blocks in organic synthesis. Our research work mainly focuses on the development of new methodology for the facile and straightforward accesses to enantioenriched? six-membered nitrogen heterocycles with high functionality via azomethine ylide-involved catalytic asymmetric [6+3]-cycloaddition reaction with various potential 6-∏-type dipolarophiles. Subsequent study will focus on the investigation of the reaction mechanism and proposed transition states; further probe the space effect and electronic effect of the chiral ligands on the enantioselectivities and yields, and the mutual effect between the catalyst and substrates, and the inherent relationships between catalysts and chemselectivity, regioselectivity and stereoselectivity in asymmetric reactions, all of which will provide the experimental and theoretical guidance for the design of new chiral catalysts and novel catalytic asymmetric reactions.