人眼晶状体调节功能的衰退和病变是影响视觉质量的核心因素，其本质是晶状体材料和微结构的损伤及演化。一方面，在晶状体现有调节理论中，Helmholtz模型与Schachar模型存在本质上的对立，导致了目前两种截然不同的临床方案和对病因认识的混乱，引发全球医学界持续十余年的争议。因此，从基础研究的角度需要明确人眼的调节理论，从临床医学的角度需要终止当前无谓的临床实验、保障患者的利益，澄清其中的混乱并终止这场争议。另一方面，晶状体病变始发于晶状体纤维中的蛋白质分子的非均匀性团聚，其团聚过程本质上对应着晶状体白内障的发展。因此，用分子动力学方法研究白内障发生和发展规律可能成为弄清白内障根本病因的突破性手段。本项目将以力学实验方法为基础并结合医学临床，探明晶状体的宏-细-微观结构和性能与其调节和病变的内在关联；反演出活体内晶状体的受力和变形规律，完善人眼晶状体调节模型；给出晶状体病变和演化宏微观机制。

Regression and lesion of human lens' accommodation ability work as the core factors impacting visual quality, and they intrinsically reveal the injury and its evolution of lens material as well as the substructure. On the one hand, the most prevalent lens accommodation theories, Helmholtz theory and Schachar theory, are fundamentally contrary to each other, which leads to the chaos of cognition towards lens pathogenesis and the two corresponding therapy methods. The dabate between these two accommodation theories have been last over ten years and it will go on unless we can clarify the real accommodation mechanism in theory research which in turn aborting unnessary clinical experiments and protecting patients' benefits. On the other hand, the lesion of lens origins in non-uniform agglomeration of lens protein molecules that is related to the development of cataract. Thus, molecular dynamics may work as a strategic breakthrough to clarify the cause and development of cataract. This research will base on systematic mechanical experiments, aiding with clinical tests, to clarify lens' macro-meso- micro structure as well as the corresponding mechanical properties and their intrinsic links to accommodation and lesion mechanisms. Furthermore, through deducing the law of load versus deformation in vivo human lens, this work will better lens accommodation model and finally reveal the mysteries of the lesion and evolution mechanism of human lens in macro-meso-micro level.