细胞-细胞粘附在大量重要的生命过程中起着关键性作用，对其研究具有重要的理论和应用价值。细胞-细胞粘附不仅取决于粘附蛋白特性，还与所处的细胞力学微环境和膜上微结构密切相关。由于分子热扰动所引起的细胞膜间的波动力排斥作用与受体-配体蛋白的相互吸引作用相当，使得波动力对细胞-细胞粘附过程必然产生重要影响。然而，波动力对细胞-细胞粘附过程的作用迄今尚不清楚。.本项目以波动力对细胞-细胞粘附过程中脂筏聚集与相分离的影响为突破口，系统地研究细胞-细胞粘附过程中的波动力调控机制。通过实验，并结合相关计算模型，探明关于波动力诱导的脂筏相分离的分子调控过程；应用统计力学方法，进一步给出波动力对细胞-细胞粘附的调控机制，并确定波动力与脂筏-粘附蛋白亲和性的耦合效应对脂筏相分离的促进作用。本项目对于在分子尺度上理解细胞粘附、拓展并深化认识波动力本身及其对细胞生命过程的影响具有深刻意义。

Cell-cell adhesion plays a key role in a lot of important life process, and its research has important theoretical and application value. The cell-cell adhesion depends not only on adhesion protein properties, also with micro cell mechanics environment and is closely related to the membrane microstructure. Since the undulation repulsion force between cell membranes caused by molecular thermal disturbances is equivalent to the mutual attraction force of receptor-ligand proteins, interactions must have an important impact on cell-cell adhesion. However, the role of the undulation force in the cell adhesion process remains unclear yet. .This project takes the influence of the undulation force on lipid raft aggregation and phase separation in the process of cell-cell adhesion as a breakthrough point to systematically study the undulation regulation mechanism in the process of the cell adhesion. The molecular regulation of lipid raft phase separation that the undulation induced was investigated by confocal microscopy and multicomponent membrane adhesion model. The mechanism of undulation on cell-cell adhesion was further studied by statistical mechanics method. This project is of great significance for understanding cell adhesion extension at the molecular scale and deepening the understanding of the impact of undulation force on cell life processes.