基于钯催化beta-碳消除的碳碳键切断

过渡金属催化的碳碳键断裂一直是有机合成反应中极具挑战性的课题之一。本研究希望通过钯催化beta-碳消除来实现碳碳键的选择性切断，尤其是热力学上更稳定的Csp3-Csp3键的切断，主要内容集中在以下三方面：1）寻找产生适合beta-碳消除前体的新方法；2）将钯催化beta-碳消除反应与钯催化的其他转化相结合来构建复杂有机化合物；3）通过该合成方法实现对自然界广泛存在的醇类天然产物的精加工。

C-C bond cleavage by transition metals has been considered to be one of the most challenging goals in organic synthesis. The goal of this project is to realize selective C-C bond cleavage via palladium-catalyzed beta-carbon elimination, especially the cleavage of thermodynamically stable Csp3-Csp3 bond. The main contents including: 1) find new method for the generation of the precursor that can undergo beta-carbon elimination; 2)construct complex organic compounds through a combination of palladium-catalyzed beta-carbon elimination and other Pd-catalyzed transformations. 3) develop finishing precessing for natural alcohol by using this new synthetic methodology.