通过对高分子结构的设计实现其性质和功能的精确设计和调控是当前化学和材料科学的重要前沿热点领域之一，也是当前高分子科学的一个重要发展方向。脱氧核糖核酸（DNA）作为一类天然的生物大分子，具有序列可编程、纳米级尺寸、精确识别、易于合成等性质，在纳米科学和材料科学等领域迅速发展。本项目拟通过分子设计，将具有优异特性的生物大分子DNA与多种具有不同环境响应性的合成高分子通过共价键连接，获得一系列双亲性DNA/合成高分子杂化体。利用DNA的构象互变和合成高分子对环境的刺激响应性，系统研究这些双亲性杂化体在溶液中的组装行为以及环境刺激对双亲性杂化体组装形貌的调控，并拟通过荧光包裹实验和金纳米颗粒的外围负载实验研究其组装机理及其潜在的应用领域。我们将运用飞行时间质谱、圆二色谱、凝胶电泳、透射电镜和动态光散射等技术对双亲性杂化体的组装及其形貌转变展开系统研究。

The precise control of the polymers' properties and functions via rationally designing polymers' structures has attracted increasing attention in the areas of polymer chemistry and nano-material science. One important strategy toward functionalized nano-structures and nano-devices is the application of oligonucleotide (DNA) due to its inherent base-pairing fidelity and sequence programmability. In this project, we plan to prepare a series of amphiphilic DNA block copolymers by introducing the macromolecule DNA as a hydrophilic component to link with various synthetic polymers through covalent linkage. Furthermore, we will systematically investigate their self-assembly behavior in solution, as well as morphologic control of the assembled nanostructures, depending on both conformational change of DNA sequence and stimuli responsiveness of polymers. The assembled structures and assembly progress will be characterized by transmission electron microscopy (TEM), atomic force microscope (AFM), dynamic light scattering (DLS), and fluorescent experiments.