Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine.
Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine.
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两亲性 DNA 有机杂化物：纳米科学中的功能材料及其在生物医学中的潜在应用
DOI：
10.3390/ijms19082283
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发表时间：
2018-08-03
影响因子：
5.6
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Zhao Z;Du T;Liang F;Liu S
由于可寻址性和可编程性，DNA不仅被应用于构建静态的纳米结构，如二维和三维DNA纳米结构，而且还被应用于设计动态纳米器件。此外，DNA可以与疏水有机分子结合成为一种新的两亲性构件，然后自组装成纳米材料。特别值得注意的是，最近的一项最新研究将我们的注意力转向了两亲性DNA有机杂交种，包括小分子修饰DNA（脂质DNA，荧光分子DNA等），DNA嵌段共聚物和DNA-树突杂交种。本文主要综述了其自组装行为的研究进展及其在纳米材料和生物医学方面的潜在应用。本文还简要讨论了两亲性DNA有机杂交体在纳米科学和生物医学方面的实际应用。
Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials. Of particular note, a recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids including small molecule modified DNA (lipid-DNA, fluorescent molecule-DNA, etc.), DNA block copolymers, and DNA-dendron hybrids. This review focuses mainly on the development of their self-assembly behavior and their potential application in nanomaterial and biomedicine. The potential challenges regarding of the amphiphilic DNA organic hybrids are also briefly discussed, aiming to advance their practical applications in nanoscience and biomedicine.
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