理想的可吸收多孔镁椎间融合器具有成骨诱导性好、力学强度佳、降解抗性足等优势因而拥有较好的应用前景，课题组前期实验结果也提示镁融合器的解剖学外形设计可通过优化椎间隙镁离子浓聚这一机制进一步提高椎间骨性融合效果，然而：1）由于制作工艺的限制，镁材料的多孔结构难以精确控制，故能同时实现合理降解速率、足够力学强度、优秀成骨诱导作用的镁融合器的理想多孔结构尚未明确；2）目前符合国人终板解剖学特征的融合器形态尚不清晰，因而具有材料学、形态学双方面先进的解剖型多孔镁融合器的生物力学优势也有待进一步论证。近年来随着科技的发展,镁材料的多孔三维结构已精确可控，故本项目拟通过体内外实验探讨镁融合器的理想的多孔结构，并同时结合前期研究基础和实验方法制作出符合国人颈椎终板普遍凹陷特点的解剖型多孔镁融合器以评估其生物力学优势。本项目为镁融合器的改进提供了方法学基础及理论依据。

Absorbable porous magnesium interbody cage has an ideal application prospect because of its good osteogenic induction and good biomechanical strength, furthermore, the results of pre-experiments also indicated that anatomical morphology of magnesium cage could improve interbody fusion through optimizing histological distribution of magnesium ion at the intervertebral space. However, there are two issues needs further researches currently. 1) The internal structure of porous magnesium is difficulty to be well controlled due to technical limitation, therefore, the ideal porous structure which can well balance the three of reasonable degradation speed, sufficient biomechanical strength and significant osteogenic induction effect remains unclear; 2) Anatomical cage which meets cervical endplate of Chinese is still under exploring, thus biomechanical benefit of anatomical porous magnesium cage which is believed to have both advantages of material and morphology requires further studies. Recently，porous 3D structure of magnesium scaffolds can be well-controlled with the development of technology, so the current project is designed to find an ideal porous structure of magnesium cage through in vivo and in vitro experiments, in addition, anatomical porous magnesium cage which meets the characteristics of Chinese cervical endplate will be fabricated and its biomechanical benefit will be tested. This study will provide methodological and theoretical basis for magnesium cage improvement.