Quantitative analysis of near-implant magnesium accumulation for a Si-containing coated AZ31 cage from a goat cervical spine fusion model.
Quantitative analysis of near-implant magnesium accumulation for a Si-containing coated AZ31 cage from a goat cervical spine fusion model.
复制标题
对山羊颈椎融合模型中含硅涂层 AZ31 融合器的近种植体镁积累进行定量分析。
DOI：
10.1186/s12891-018-2027-5
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发表时间：
2018-04-04
影响因子：
2.3
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Zhang F;Xu H;Wang H;Geng F;Ma X;Shao M;Xu S;Lu F;Jiang J
背景镁基植入物降解释放的镁（Mg）被认为能有效促进成骨，然而，针对镁基椎间融合器的研究有限，从未报道融合成功。由于过量的镁积累可以抑制新骨的形成，本研究旨在解释可能的原因，镁基融合器融合失败的椎间镁积累和由此产生的interbody fusion.MethodsThe实验笼由镁合金（AZ 31）基板和含硅（Si）的涂层。将24只山羊C3/C4和C5/C6植入Cage或自体髂嵴植骨（对照组），术后3、6、12和24周进行分析。记录椎间镁浓度、镁相关钙（Ca）/磷（P）比值、影像学评价和组织学检查结果，分析椎间融合器腐蚀、镁蓄积和椎间融合三者之间的关系。并且这些增加的浓度可以持续到手术后12周，表明相对快速的腐蚀过程。镁水平仅在术后24周显著降低，但这些水平仍高于对照组。此外，发现Mg广泛分布在椎间隙，因为甚至在椎体的后边界处也可以检测到高Mg浓度。在这种镁积累的个人资料，椎间融合没有实现，所示的钙/磷比值下降，低CT融合分数和阴性的组织学results.ConclusionsIntervertebral过量镁积累可能是椎间融合失败的主要原因。定量镁分析可以深入了解笼退化和生物反应之间的关联。
BackgroundMagnesium (Mg) released from Mg-based implants degradation is believed to be effective in improving osteogenesis, however, studies focusing on Mg-based interbody cages are limited and fusion success was never reported. As excessive Mg accumulation can inhibit new bone formation, this study is designed to explain the possible reasons for the fusion failure of Mg-based cages by analyzing the relationships between the intervertebral Mg accumulation and the resulting interbody fusion.MethodsThe experimental cage was consisted of magnesium alloy (AZ31) substrate and Silicon (Si) -containing coating. C3/C4 and C5/C6 of 24 goats were implanted with cage or autologous iliac crest bone graft (Control group), which were analyzed at 3, 6, 12, and 24 weeks post-operatively. Intervertebral Mg concentrations, Mg-related Calcium (Ca)/ Phosphorus (P) ratios, radiological evaluations and histological findings were recorded for analyzing the relationships between the three of cage corrosion, Mg accumulation, and interbody fusion.ResultsIntervertebral Mg levels were significantly increased after cage implantation, especially in the areas that were closer to the cages at 3 weeks post-operatively, and these increased concentrations could persist up to 12 weeks post-operatively, indicating a relatively rapid corrosion process. Significantly lower Mg levels were only found at 24 weeks post-operatively, but these levels were still higher than those of the control group. In addition, Mg was found to be widely distributed at the intervertebral space since high Mg concentrations could even be detected at the posterior boundary of the vertebral body. Under this Mg accumulation profile, interbody fusion was not achieved, as indicated by the decreased Ca/P ratios, low CT fusion scores and negative histological results.ConclusionsIntervertebral excessive Mg accumulation might be the primary reason for interbody fusion failure. Quantitative Mg analysis can offer insight into the association between cage degeneration and biological response.
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影响因子：
3.7
作者：
Nguyen TY;Liew CG;Liu H
通讯作者：
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作者：
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DOI：
10.1016/j.msec.2013.11.041
发表时间：
2014-03-01
影响因子：
7.9
作者：
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通讯作者：
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影响因子：
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作者：
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