糖尿病视网膜病变（DR）是糖尿病最严重的并发症之一,我国发病人口数量大。《新英格兰医学杂志》2012年文章指出,应着重提高DR检查技术水平,实现早期诊断。相位对比显微CT具有超高空间分辨力（亚微米量级）、超高密度分辨力（是吸收显微CT的1000倍）和辐射剂量低等优势;前期研究表明,该技术可区分视网膜4-5层结构,为视网膜显微结构病变研究提供了全新方法。基于显微MR的DCE-MRI是评价DR动物模型视网膜微循环功能改变的有效方法。本项目拟使用相位对比显微CT和显微MR技术,研究不同病程DR大鼠模型视网膜微循环功能变化和显微解剖结构（亚微米量级）变化的演变规律,确立DR早期诊断的参考时间点及病变特征。本项目组对视网膜相位对比显微CT成像和DR的DCE-MRI研究做了大量前期研究工作。本项目是前期研究工作的深入。该研究将为DR早期诊断提供影像学依据,具有重要的科学价值。

Diabetic retinopathy(DR) is the most common and serious complication associated with diabetes, which is the high morbidity in our country. Examination technology of DR needs to be improved and early treatment is expected. Phase contrast microtomography has good quality of high spatial resolution, density resolution and low radiation. This technololgy can resolve subtle composition of retina and provide new support for retinal diseases. DCE-MRI based on MR microscopy is an effective method in evaluating retinal microcirculation. Based upon phase contrast microtomography and MR microscopy, we will try to quantitatively ananlyze the regular pattern of retinal functional and anatomical change from animal(rat) experiment, and facilitate the assessment of early diagnostic timing and characteristics. This project is the further study based on early work and will provide early imaging and scientific foundation.