研究新的合成方法学，并运用新方法完成复杂天然/非天然产物的新型剪裁一直是合成化学的重要研究内容。本项目拟对Pd 催化norbornene 介导的芳基卤化物本位和邻位活化研究概念的进一步深入研究，以卤素邻位带有亲核性的芳香烃为研究对象，实现一个化学反应步骤完成3 个化学键的连接，同时形成2 个新的环。并将该方法应用到具有生物活性的复杂结构的天然与非天然的重要母核的合成中。

To develop new synthetic methodolgies and using these new discoveries for natural/non-natural product tailoring is of great interests in synthetic organic chemistry. We are focusing on the development of novel Pd-catalzed norbornene-mediated C-H activation/cyclization reactions to form 3 new chemical bonds with 2 new rings by utilizing aryl halides with a nucleophilic sutituent meta to the halogen atom. The further application would be on the construction of important natural/non-natural product skeletons.