我们首先报告了全氟辛烷磺酸（PFOS）体外抑制11β羟基类固醇脱氢酶2（11βHSD2）活性。最近发现11βHSD2与低体重出生儿（LBWI）关系密切，同时申请者还报道了PFOS可使仔鼠体内脂类代谢障碍及母鼠胎盘中IGF1含量降低，进而导致新生儿低体重。在我国，LBWI出生比例逐步上升，WHO调查发现其与环境污染物密切相关。PFOS是近几年新出现的环境污染物并被广泛利用。在人群中PFOS与LBWI关系的研究尚未见报道，综合上述发现及国内外研究进展。因此，申请者设计本课题拟开展以LBWI人群为基础的病例-对照研究，收取母体血液、胎盘、尿样和胎儿脐带血及尿样等样本，利用LC-MS-MS、ELISA、酶学、分子生物学等手段检测PFOS、GC、IGF1/2、11β-HSD2及胎盘功能，阐明PFOS等危险因素与LBWI之间的关系，为制定相应的防止环境污染法规提供科学依据。

Recently we first report that perfluorooctane sulfonate (PFOS) inhibit 11β hydroxysteroid dehydrogenase 2 (11βHSD2) activity in vitro, meanwhile 11βHSD2 is closely related to low birth weight infant (LBWI). We also found that exposure of pregnant rats to PFOS is associated with intrauterine growth restriction, IGF1 downregulation, and decreased cholesterol. LBWI proportion gradually increased in china, which is closely related to the environmental pollutants based on the WHO survey. PFOS,as emerging environmental pollutants,is extensive used in recent years. There is no report about PFOS epidemiological study in china now. Thus the applicant designed this project to be carried out case - control epidemiological studies based on low birth weight infant population, and collect fetal and mother's serum,urine and placenta. In this project we aimed to assess maternal-fetal PFOS exposure, and the relationship among in utero PFOS, GC, IGF1/2 or 11βHSD2 and LBWI in neonates and mothers by LC-MS-MS and ELISA and Bioscan enzymatic assays. We also detect the PFOS level and metabolomics changes of the maternal serum and cord blood in order to provide a scientific basis for the formulation of appropriate laws and regulations.