Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
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DOI：
10.1371/journal.pone.0078888
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Chu Y
中科院分区：
文献类型：
--
作者：
Zhao B;Li L;Liu J;Li H;Zhang C;Han P;Zhang Y;Yuan X;Ge RS;Chu Y
全氟辛烷磺酸（PFOS）是一种合成材料，几十年来一直广泛用于工业应用。接触全氟辛烷磺酸与成年期睾丸激素水平下降和睾丸间质细胞受损有关。然而，全氟辛烷磺酸在子宫内对胎儿间质细胞的影响知之甚少。本研究调查了全氟辛烷磺酸对FLC功能的影响。妊娠的Sprague道利雌性大鼠从妊娠第11-19天（GD）经口灌胃接受溶剂（0.05%吐温20）或全氟辛烷磺酸（5、20毫克/千克）。在GD 20，检测睾丸激素（T）的产生，FLC数量和超微结构，睾丸基因和蛋白表达水平。研究结果表明，接触全氟辛烷磺酸影响了FLC的功能，表现为T生成减少、FLC受损、FLC数量减少以及子宫内类固醇生成能力和胆固醇水平降低。目前的研究表明，全氟辛烷磺酸是一种雄性生殖系统内分泌干扰物，因为它会导致T细胞生成减少和大鼠胎儿间质细胞受损。
Perfluorooctane sulfonate (PFOS) is a synthetic material that has been widely used in industrial applications for decades. Exposure to PFOS has been associated with decreased adult testosterone level, and Leydig cell impairment during the time of adulthood. However, little is known about PFOS effects in utero on fetal Leydig cells (FLC). The present study investigated effects of PFOS on FLC function. Pregnant Sprague Dawley female rats received vehicle (0.05% Tween20) or PFOS (5, 20 mg/kg) by oral gavage from gestational day (GD) 11–19. At GD20, testosterone (T) production, FLC numbers and ultrastructure, testicular gene and protein expression levels were examined. The results indicate that exposures to PFOS have affected FLC function as evidenced by decreased T production, impaired FLC, reduced FLC number, and decreased steroidogenic capacity and cholesterol level in utero. The present study shows that PFOS is an endocrine disruptor of male reproductive system as it causes reduction of T production and impairment of rat fetal Leydig cells.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
Ge, RS;Dong, Q;Hardy, MP
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