本项目围绕有机小分子催化的[(2+2+2)+1]的不对称串联反应，以并环及含季碳手性中心的全取代哌啶类化合物不对称合成为目标，研究与发展：1）串联的不稳定脂肪亚胺参与的aza-Henry反应和2）双亲核试剂参与的并环哌啶类化合物的合成方法学。全取代哌啶现有不对称合成方法局限较大，本项目的研究不仅有助于促进全取代哌啶多样性合成，而且有利于发展有机小分子催化串联反应相关研究的推进。

This project aims at organocatalysted cascade/domino [(2+2+2) +1] reaction for the asymmetric synthesis of fully substituted piperidine, especially those which containing spiro ring or/and quaternary carbon center. Capitalizing on the screening of Michael donor, Michael receptor, nucleophilic reagent, bi-nucleophilic reagent, the protocol of construction of fully substituted piperidines with screw ring or, and a chiral quaternary carbon center will be developed.: 1) aza-Henry reaction of unstable imines, and 2) research and development of bi-nucleophile reagents libraries. The significance of this project lies in that the above-mentioned targets are of great synthetic value, while current methods for their preparation need to be improved. In summary, this project will promote the chemistry of piperidine and organocatalyzed tandem reaction.