多糖类物质在医药和保健食品方面具有广泛用途，现已成为新药研究焦点目标之一。课题组前期研究发现桑葚多糖具有良好的抗酒精性肝损伤作用，是潜在的抗化学性肝损伤治疗性制剂，值得深入研究。但是，其抗化学性肝损伤的“构-效”关系和作用机制均不清楚，严重制约了桑葚多糖的深度开发利用。本项目拟在现代科学技术指导下，选择桑葚多糖为研究对象，对其进行提取、分离、纯化和结构鉴定研究；在此基础上，通过各种手段对其进行分子结构修饰，获取桑葚多糖衍生物，采用药理模型研究桑葚多糖及其衍生物的药效作用，探索其“构-效”关系。此外，从信号通路、分子表达、细胞表达等不同角度对桑葚多糖及其衍生物抗化学性肝损伤的作用机理进行深入研究。该项目研究，一方面可以基本弄清桑葚多糖抗化学性肝损伤的药效情况、“构-效”关系以及作用机制，为其深度开发利用提供科学依据；另一方面，可以为大分子物质的“构-效”关系研究提供可供参考的模式和思路。

Polysaccharide, having widely uses in medicine and health foods, has now become one of the focuses on new drug research. Our research team found that mulberry polysaccharide (MPS) had good resistance to alcoholic liver damage, as a potential chemical resistance liver injury therapeutic agent, is worth further investigation. However, its "structure – effect” relationship and mechanism are not clear, and severely restricted the depth development and utilization. This project is guided by modern science and technology, chooses mulberry polysaccharide as the research object, carry out extraction, separation, purification and structure identification research. On this basis, modify its molecular structure and obtain mulberry polysaccharide derivatives. Then, pharmacological model is adopted to study the efficacy of mulberry polysaccharide and its derivatives, explore the relationship between "structure and effect". In addition, from different angles, such as signal pathways, molecular expression and cells expressing, to further research mechanism of mulberry polysaccharide and its derivatives against chemical liver injury. The project research, on the one hand, can basically clarify efficacy of liver injury, “structure – effect” relationship and mechanism of action on mulberry polysaccharide, and provide scientific basis for its further development and utilization. On the other hand, it can provide reference pattern and train of thought for “structure – effect” relationship research on macromolecular substances.