可控制的给药系统因其可选择性的控制药物的输送和释放，可提高药物分子的利用效率和降低药物潜在的副作用，一直以来是药物输送领域的重要的研究方向。本申请将从两方面合成并构建光调控的聚合物药物载体。1）利用光活性交联剂在双亲高分子的亲油端构建网状结构形成交联聚合物。其将可能形成更稳定的药物包载胶束；2）光活性的单体通过乳液聚合构建药物包载微粒。研究各种条件下光活性聚合物的交联程度、分子量、光活性聚合物形成药物载体胶束或微粒的大小等各种因素与药物包载量和药物光控释放效率之间的构效关系。通过上述系统研究，我们期望发现聚合物、药物载体和光照药物释放效率之间的规律，并不断优化这类光活性药物载体。我们将试验某些药物分子（如阿霉素、紫杉醇等）在上述光活性高分子聚合物中的包载并研究它们在细胞中药物释放的光学调控，并有望进一步研究它们在动物模型中药物分子的可控释放。

Due to selective controlled release of drugs, intelligent drug delivery system have been proved to enhance the drug effectiveness and reduce the side effect, and has become one of the important reseach areas. In this proposal, we intend to design and synthesiz two photocontrollable drug release systems. 1) we will synthesize crosslinked biblock copolymers with photolabile crosslinker and form more stable drug encapsulated micelles with these polymer. 2)we will synthesize photosensitive polymeric nanoparticles with photolabile monomers. For both systems, we will study the degree of crosslinking, molecular weight,size of micelles or nanoparticle under different synthetic conditions, and their effect on drug encapsulation and phototriggered releasing efficiency. Through these studies, we hope to find several candidates with high stability and phototriggered releasing efficiency. Further, nanoparticles with encapsulated drugs will be evaluated in cells and their photocontrol of drug release will be demonstrated. This study will provide promising information to further extend its application of controlled release in model animal.