非金属量子点 如碳量子点，因不含有重金属粒子，对生命体系不存在潜在的长期毒性及环境污染，但却具有半导体量子点的光学特性，因此在材料科学、物理科学、化学科学等各方面都得到广泛的应用，特别是在生物医药和成像领域。我们前期发现以叠氮咪唑为原料可以制备的富氮的氮量子点，而且具有优良光学性质。本项目拟在此基础上研究各种不同结构的杂环化合物制备氮量子点的可能性,特别是长波长荧光的氮量子点，探讨制备量子点的原料结构与量子点制备的可能性及其光学性质的关系，阐明氮量子点形成的可能机制。同时，对形成的氮量子点进行表面靶向修饰，用于肿瘤细胞的特异性检测和细胞成像，为氮量子点的进一步应用奠定基础。

Non-metal quantum dots (such as C-dots) have little potential long-term toxicity and enviromental contamination, but maintain the similar optical properties as semi-conductive quantum dots. They have been widely applied in material science, physical science, chemical sciences, esp. in biomedicine and bioimaging. In our previous study, we accidently produced a new kind of nitrogen-rich quantum dots (N-dots) with 2-azidoimidzole as starting material under mild conditions, and the N-dots showed excellent optical properties. Here, we plan to prepare N-dots with various heterocycle molecules,esp. N-dots with red fluorescence emission, and study the relationship of N-dots formation and their optical properties with the molecular structures of starting materials and demonstrate the detailed mechanism of N-dots formation. In addition, we further modified the surface of N-dots and labelled with some target molecules for detection of cancer cells and cell imaging. This will further expand the applications of N-dots