作为一种重要的活泼中间体，二氟卡宾在有机反应中已有广泛应用，但是二氟卡宾化学还有待深入研究。申请人拟在以下几方面展开工作：(1) 开发二氟卡宾试剂。设计合成受热后即可脱羧释放二氟卡宾的试剂，解决目前试剂中存在的挥发性或吸水性强、需要在碱性或高温等条件下使用的问题。(2) 发展二氟卡宾的反应类型。二氟卡宾反应类型的发展已经遇到瓶颈。以过渡金属催化二氟卡宾转移的方式可对其有效拓展。(3) 以二氟卡宾实现三氟甲硫/氧基化。由[:CF2]与[F-]组合实现三氟甲硫/氧基化，为有效构建 [18F]CF3X (X = S, O)基团提供重要的方法。(4) 实现二氟卡宾与二烯的[4+1]或[2+2+1]环化反应。此两类环化反应一直是二氟卡宾化学的难题，需要合理设计底物和反应条件才可实现。通过以上几项内容的研究，进一步推动二氟卡宾化学的发展。

Difluorocarbene has found widespread application in a variety of organic transformations, but the chemistry of difluorocarbene needs to be further explored. The research program will focus on this chemistry by broadening the utilities of difluorocarbene. Firstly, efficient and mild difluorocarbene reagents will be developed. Many known reagents suffer from high volatility or hygroscopicity, and/or basic or harsh reaction conditions to generate difluorocarbene. The reagents which can release difluorocarbene by decarboxylation under warming conditions will be designed and synthesized. Secondly, new reaction classes will be spawned. The area of the transformation of difluorocarbene is now bottlenecked by the limited reaction classes. The transition-metal-catalyzed transfer of difluorocarbene may lead to an explosive growth of difluorocarbene’s application in organic reactions. Thirdly, the protocols for trifluoromethylthiolation and trifluoromethoxylation with difluorocarbene will be explored. The realization of trifluoromethylthiolation and trifluoromethoxylation by using the [:CF2]/[F-] system will provides convenient and straightforward strategy for the installation of [18F]CF3X (X = S, O) moiety. Lastly, the [4+1] cyclization of 1,3-diene or [2+2+1] cyclization of olefins with difluorocarbene will be investigated. These cyclization reactions remains significant challenges in the chemistry of difluorocarbene. They should be able to be successfully achieved by the selection of suitable substrates and reaction conditions. We plan to move the chemistry of difluorocarbene forward by accomplishing the above work.