结合目前氟化学的研究重点与难点，研究含氟有机盐的合成与反应，着力解决氟化学前沿领域中存在的一些难点问题。(1)合理利用氟资源发展简便的含氟有机盐试剂。充分利用丰富的廉价含氟资源制备实用高效的含氟有机盐试剂。(2)发展高效的三氟甲氧基化方法。三氟甲氧基化发展缓慢，主要有几方面原因：亲核反应中间体CF3O-或CF3OM易分解；过渡金属络合物中间体R-M-OCF3还原消除困难；CF3O•不容易产生且目前的自由基方法难以控制反应的区域选择性。 (3)发展温和高效的五氟硫基化方法。五氟硫基的构建是氟化学的一个重大难题。直接五氟硫基化是最简便合成五氟硫基化合物的方法，但方法极其匮乏。(4)发展新颖的18F标记方法。18F标记分子的合成是PET技术核心基础之一。目前方法局限于单氟基团的标记，将突破这一局限性，实现多氟基团如氟烷氧基、氟烷硫基、含氟烯烃及含氟环状结构等的标记。

Based on the present research focuses in fluorine chemistry, the synthesis and reaction of fluorine-containing organic salts will be investigated in an attempt to solve some difficult and challenging problems. Firstly, inexpensive and abundant fluorinated resources will be employed as starting materials to prepare the valuable fluorinated organic salts. The full and rational exploitation of the fluorinated resources will facilitate the progress and development of fluorine chemical industry and academic research. Secondly, efficient trifluoromethoxylation methods will be developed. Trifluoromethoxylation remains challenging due to the following reasons: the key intermediates (CF3O- or CF3OM) in nucleophilic reactions would decompose easily; reductive elimination of transition metal complexes R-M-OCF3 cannot occur smoothly; it is difficult to generate the CF3O• radical and the regio-selectivity in radical trifluoromethoxylation is hard to control. Efforts will be made to provide solutions to these problems. Thirdly, mild and effective pentafluorosulfanylation strategies will be established. The installation of pentafluorosulfanyl moiety is a significant challenge in fluorine chemistry. Direct pentafluorosulfanylation is a straightforward method to obtain SF5-containing molecules. However, few mild and efficient approaches exist. The discovery of pentafluorosulfanylation reagents and reactions are highly desirable to make a breakthrough in this field. Last but not the least, convenient and efficient 18F-labeling methods will be developed. 18F-labeling is one of the key points of PET (positron emission tomography) technique. However, current labeling methods have been limited to the labeling of monofluorinated substituents. We will overcome this shortcoming to achieve the 18F-labeling of multi-fluorinated substituents such as fluoroalkoxy, fluoroalkylthio, fluoroalkene and fluorocycle units.