基于金属/电介质多层薄膜双曲超材料等离激元的超灵敏生物传感芯片研究

免标记分析技术的干扰因素较少，具有较高的实证性，因此表面等离激元共振（SPR）生物传感技术在药物研究中具有较大应用潜力，但目前最主要的问题是小分子分析物响应灵敏度不足。本项目提出以光栅耦合（GC）激发金属/电介质多层薄膜结构双曲超材料（HMM）的多个等离激元模式，用于样品折射率的超灵敏传感测量，灵敏度可达36000nm/RIU，折射率分辨率达到10^-9RIU量级水平。研究多种金属/电介质多层薄膜HMM的介电特性、等离激元色散特性，获得几种金属/电介质多层薄膜HMM的结构参数、HMM表面等离激元的光栅耦合条件，实现表面等离激元和体等离激元多个模式的同时激发，建立波长调制和角度调制方法；制备并获得几种GC-HMM超灵敏传感芯片，设计并搭建小型化芯片信号读取系统，实现并达到小分子响应灵敏度，为药物分析等小分子相互作用动力学测量提供一种超灵敏生物传感芯片和免标记直接检测手段。

Label-free analysis technology has less interference factors and higher empirical performance. Therefore the surface plasmon resonance (SPR) biosensor technology has great application potential in medical research. But now the main problem is that the response sensitivity for the detection of lower-molecular-weight analyte is insufficient. In this project, we propose multiple plasmon modes of metal/dielectric multilayer film structure hyperbolic metamaterials (HMM) excited by using the grating-coupling (GC) technique, for sensing and measurement of sample refractive index, the maximum sensitivity of sensor is up to 36000 nm per refractive index unit (nm/RIU) and the refractive index resolution can reach the level of 10^-9RIU. According to the researches on dielectric properties of HMM with metal/dielectric multilayer film structure and plasmon dispersion characteristics, we acquire structure parameters of several metal/dielectric multilayer films HMM and the grating-coupling condition of the HMM surface plasmon. Thus, we realize the simultaneous excitation of multiple modes of surface plasmon and bulk plasmon, and establish wavelength modulation and angle modulation methods. By fabricating several GC-HMM extreme sensitive sensor chip, designing and building a miniaturized chip signal reading system, we achieve the extreme sensitivity of detection of lower-molecular-weight biomolecules, and provide an extreme sensitive biosensor chip and label-free direct analysis methods for the kinetic measurement of small molecule interaction.