Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation
Resonance plasmonic gold microwell arrays for high-performance surface plasmon resonance imaging based on polarization contrast modulation
复制标题
基于偏振对比度调制的用于高性能表面等离子体共振成像的共振等离子体金微孔阵列
DOI：
10.1117/1.jnp.13.012507
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发表时间：
2018-11
影响因子：
1.5
通讯作者：
Wang Xiaoping
中科院分区：
文献类型：
--
作者：
Sun Yi;Cai Haoyuan;Wang Xiaoping
抽象。表面等离子体共振成像（SPRi）传感器提供的通量和无标记的多分析物询问能力在生化分析中获得了相当大的兴趣。在这里，我们报告了一种基于偏振对比度调制的光学平台，其中三维等离子体阵列作为传感芯片，以消除背景共振，并通过限制SPR大大提高了在微孔结构中的电磁场响应。此外，该传感器还能提供极高的对比度和信噪比，并能实现极高的灵敏度响应（1.52 × 105像素/ RIU）。此外，信号背景比提高到40。低浓度检测限可达5.38 × 10 − 7 RIU，提高了1个数量级。在生物分子相互作用分析中，该传感器可以检测5.12 × 104倍稀释的牛血清白蛋白抗体溶液。特殊的芯片架构和高图像质量引入了使用SPRI检测的阵列筛选方法。
Abstract. The throughput and label-free multianalyte interrogation ability provided by surface plasmon resonance imaging (SPRi) sensors has gained considerable interest in biochemical analysis. Here, we report an optical platform based on polarization contrast modulation, in which a three-dimensional plasmonic microwell array is used as a sensing chip to eliminate background resonance and greatly enhance the electromagnetic field response in the microwell structure by confining the SPR. In addition, the sensor can provide an extremely high contrast and signal-to-noise ratio and can achieve a very high sensitivity response (1.52 × 105 pixel / RIU). Additionally, the signal-to-background ratio is improved to 40. The low-concentration limit of detection can reach 5.38 × 10 − 7 RIU, which is 1 order of magnitude improvement. In biomolecular interaction analysis, the sensor can detect a 5.12 × 104-fold diluted bovine serum albumin antibody solution. The special chip architecture and high image quality introduce an array screening method using SPRi detection.
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影响因子：
8.4
作者：
I. Mannelli;V. Courtois;P. Lecaruyer;G. Roger;M. Millot;M. Goossens;M. Canva
通讯作者：
I. Mannelli;V. Courtois;P. Lecaruyer;G. Roger;M. Millot;M. Goossens;M. Canva
影响因子：
8.4
作者：
Xinglong Yu;Xiang Ding;Fangfang Liu;Yan Deng
通讯作者：
Xinglong Yu;Xiang Ding;Fangfang Liu;Yan Deng
影响因子：
2.4
作者：
Yi Sun;H. Cai;Xiao-ping Wang
通讯作者：
Yi Sun;H. Cai;Xiao-ping Wang
影响因子：
12.6
作者：
Piliarik, Marek;Parova, Lucie;Homola, Jiri
通讯作者：
Homola, Jiri
表面等离子体成像传感器的对比度增强偏振控制方法
影响因子：
1.3
作者：
Huang, Zihao;Wang, Xiaoping;Zhan, Shuyue;Liu, Xu
通讯作者：
Liu, Xu