自我相关属性反映了外在环境中刺激与自我之间的关系，是人与自然环境和社会环境互动的基础。但是，外在非自我相关刺激如何转变为自我相关刺激，即外在刺激自我相关属性的形成，迄今仍有待研究。以往研究表明岛叶是自我信息加工的核心脑区，颞顶联合区（TPJ）能够影响个体对外在刺激自我相关属性的判断，两个脑区的协同活动极有可能是外在刺激自我相关属性形成的关键。为验证这一假设，本项目结合脑磁图、经颅磁刺激（TMS）、以及功能磁共振，研究内部心跳与外在TMS对健康受试者岛叶与TPJ协同活动的调节，及其对外在刺激自我相关属性形成的影响。进一步，以具有自我与周围环境区分障碍的精神分裂症病人（具有幻听症状）为对象，研究病人的外在刺激自我相关属性的形成，及其与岛叶／TPJ活动之间的关系。本项目的实施不仅有助于理解个体与外界互动的神经机制，完善自我的理论体系，还将为精神分裂症等自我相关信息加工障碍疾病提供治疗思路和靶点。

Self-relatedness reflects the relationship between external stimuli and the self. It is the foundation of our interaction with the natural and social environments. However, how does irrelevant stimuli turn into self-related stimuli, i.e. the generation of self-relatedness, is yet to be understood. Previous researches indicated an overall involvement of the insula into all aspects of the self, hence is a core region of the self, whereas the temporal parietal junction (TPJ) can influence the judgement of self-relatedness of external stimuli. It is likely that the coordination between insula and TPJ could be the key underlying the generation of self-relatedness of external stimuli. To test this hypothesis, our current project utilizes MEG, TMS and fMRI to study the internal influence of heartbeat, and external influence of the TMS, on co-activities between insula and TPJ, as well as the generation of self-relatedness. Furthermore, we will target at schizophrenia with auditory hallucination, who are found to have self-environment differentiation difficulties, to study the relationship between the malfunctioning in generating self-relatedness and insula/TPJ activities. Our project would help understand the neural mechanism of our interaction with the external environment, and improve the theoretical structure of the self. It will also provide new ideas and targets for treatment of schizophrenia.