在组织工程领域，种子细胞液能否在支架表面快速铺展，并且迅速有效的进入其三维多孔结构中，都将极大地影响细胞在支架中的粘附、生长和增殖行为。因此，研究材料表面的快速浸润现象与细胞粘附之间的关系就显得非常重要。本研究拟通过相分离或冷冻干燥等技术，应用具有良好生物相容性的高分子材料制备具有多尺度复合结构的膜和组织工程支架，进而通过调控等离子体或紫外辐照时间的方式，拟制得一系列具有快速浸润速度的超亲水膜和相应的组织工程支架。在这些膜和支架上开展细胞粘附实验，研究浸润速度对细胞在这些材料表面及内部的粘附、生长和增殖行为的影响，揭示快速浸润于细胞粘附之间的关系；同时研究细胞粘附行为在具有快速浸润特性的超亲水表面和对应的超疏水、疏水和亲水表面之间的区别，丰富人们对细胞在材料表面粘附的认识，为设计新型的组织工程材料提供更多的理论和实验依据。

In tissue engineering the cells adhesion, spreading and proliferation are greatly affected by the spreading of the seeding cells solution on the surface and in the 3D structures of scaffolds. Therefore it is very important to investigate the relation between cells and fast spreading materials. This application will fabricate the superhydrophilic film and tissue engineering scaffold with fast spreading property by tuning plasma treatment or UV irradiation time using biocompatible polymers, and then cell culture experiment will be carried out on these prepared materials. How the spreading rate effect the cells adhesion, spreading and proliferation on the superhydrophilic surface or in the 3D scaffold structures will be investigated in order to demonstrate the relation between fast spreading phenomenon and cells adhesion. Meanwhile the difference of cells adhesion on fast spreading superhydrophilic surface, hydrophilic surface, hydrophobic surface and superhydrphobic surface will also be explored. This project will enrich the knowledge of the cells adhesion on the material surface and also offer more theoretical and experimental basis on constructing new typical tissue engineering materials.