Interactions between cells or proteins and surfaces exhibiting extreme wettabilities

Interactions between cells or proteins and surfaces exhibiting extreme wettabilities
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细胞或蛋白质与表现出极端润湿性的表面之间的相互作用

DOI:
10.1039/c3sm27739a
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发表时间:
2013-02
期刊:
影响因子:
3.4
通讯作者:
Joao F. Mano
Joao F. Mano
中科院分区:
化学2区
文献类型:
--
作者:
Wenlong, Song;Joao F. Mano

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蛋白质吸附和细胞粘附的调控是生物医学和组织工程领域的一个关键方面。除了对亲水/疏水表面的一般研究外,将蛋白质或细胞与表面之间的相互作用的研究扩展到两个极端的润湿范围,即超亲水性和超疏水性,具有根本和实际的意义。本文综述了近年来蛋白质或细胞在这两个特殊润湿范围内的作用。第一部分将集中在蛋白质和超亲水/超疏水表面之间的相互作用。第二部分将集中在细胞粘附在这些极端粗糙的表面。表面可以被图案化以在空间中将润湿性控制在极端值内。作为这种基板的应用,平板芯片的高通量筛选也解决了提供一种新型的生物分析支持的设计新的见解。
Regulation of protein adsorption and cell adhesion on surfaces is a key aspect in the field of biomedicine and tissue engineering. Beside the general studies on hydrophilic/hydrophobic surfaces, there are both fundamental and practical interests to extend the investigation of the interaction between proteins or cells and surfaces to the two extreme wettability ranges, namely superhydrophilicity and superhydrophobicity. This review gave an overview of recent studies on proteins or cells action on these two special wettability ranges. The first part will focus on the interaction between proteins and superhydrophilic/superhydrophobic surfaces. The second part will focus on cells adhesion on these extreme wettable surfaces. Surfaces can be patterned to control in space the wettability within extreme values. As an application of such substrates, flat chips for high-throughput screening are also addressed to offer new insight on the design of a new type of bioanalysis supports.
DOI: 10.1007/s10439-009-9661-x
发表时间: 2009-05
影响因子: 3.8
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发表时间: 2000-06-01
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影响因子: 14
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