应用封堵器介入治疗已成为先天心脏病首要的治疗选择，但目前临床应用的封堵器均存在金属异物终生存留心脏，诱发炎性反应导致严重心脏传导阻滞、心脏穿孔、需要再次开胸手术等缺陷，所以积极研发生物相容性好、可降解的封堵器迫在眉睫。由于材料自身特性和仍需依赖金属骨架的特点，虽然目前有数少学者开始本领域研究，但已试制的封堵器均由于材料限制尚无法满足临床需要。. 我们前期选择一种能够满足先天性心脏病封堵器性能要求、体内可完全降解的高分子共聚物，即PVF/AR聚合物，无需金属骨架，形状记忆开关与人体生理温度完全吻合。本课题设计利用该共聚物为原料，研发封堵器；通过系列在体、细胞学、动物实验，检测封堵器的力学和生物学性能，验证其可行性和安全性，为生物可降解封堵器的研发提供一种可行的选择。

Transcatheter intervention by nickel-titanium-alloy occluders has become one of the most common selection for congenital heart defects. However, the associated problems from the implanted occluders is still the debated deficit，for example the severe atrioventricular block, cardiac ablation. Inevitably, investigating completely biodegradable and more biocompatible occluders is necessary. Although some biodegradable materials have been tried for occluders, the study of bioabsorbable occluder complying with the clinical application has been rarely reported due to its specific molecular characteristics and manufacturing process.. We have synthesized polyvinylidene fluoride (PVDF)/acrylic rubber (ACM) blends, a biodegradable terpolymer, and tested it as a clnically, potentially good material for the occluder. The aim of this study is to produce individualized totally bioabsorbable heart occluders using 3D printing technology and polymer biodegradable materials, and then to detect the biological characteristics of the occluders from a series of in vitro and in vivo experiments.