呼吸系统疾病的发病率近年来随着大气污染、雾霾天气的增加而急剧上升，"温邪犯肺"是其主要病机之一，同时现代医学对其防治因耐药菌增多等因素而遭遇了瓶颈。"辛凉解表"是中医治疗温邪犯肺的常用治法，将中医理论与现代科学相结合诠释其内涵，将为温热型肺病的治疗提供科学依据及有效途径。我们前期研究发现辛凉解表药物中存在调控ADR、ATP synthesis、NF-κB等关键信号通路的药效物质，其药理作用与"发汗解表、能量代谢、免疫调节"密切相关。本项目通过构建温邪犯肺证候模型，开展辛凉解表代表方桑菊饮、银翘散的系统生物学研究；结合活性导向的UPLC-Q/TOF快速筛选平台，辨析辛凉解表药的药效成分；以化学生物学手段标记的关键成分进行示踪及靶点垂钓，揭示其作用靶点、通路以及网络的关联；通过方剂配伍增强相关信号转导的分子机制研究，阐述经典方剂配伍协同增效的科学内涵，阐释中医治疗"温邪表证"对证施药的科学性。

With the increasing weather haze and pollution, the incidence of respiratory diseases rises sharply in recent years. "Wenxie Fanfei" is the main pathogenesis. Meanwhile, modern medical in prevention and treatment of lung inflammation has encountered a bottleneck caused by increasing of drug-resistant bacteria. "Xinliang Jiebiao" is one of the common methods in traditional Chinese medicine in the treatment of "Wenxie Fanfei". Combined with Chinese medicine theory and modern science to interpret its connotation, might be an effective way to solve this problem. In our previous study, we found that there were some medicinal composition in Xinliang Jiebiao drugs could regulate the signaling pathways of ADR, ATP synthesis and NF-κB. All these effects were closely related with "sweating, energy metabolism and immune regulation". In this present study, systems biology research on Sang Ju Yin and Yin Qiao San were build a syndrome model of "Wenxie Fanfei". We try to identify the effective compounds rapidly by bioactivity-based UPLC-Q/TOF screening system; reveal its associated targets, pathways and networks using cell imaging and protein target fishing technology. Through the study of molecular mechanism of enhance the signal transduction by the prescription compatibility, the scientific connotation of compound compatibility synergies will be investigated, and the scientific justification for adapting the remedy to "Wenxie Fanfei" by traditional Chinese medicine might be clarified.