本课题组前期研究显示舌鳞癌侵袭转移与miR-138、SOD2等基因的异常、上皮间质转化（EMT）以及力学性能的改变有关。为了进一步研究力学性能在舌鳞癌侵袭转移过程中所起的作用，本课题首先研究伴或不伴淋巴结转移的舌鳞癌患者细胞力学性能（如弹性模量）的变化及其与侵袭转移相关基因（miR-138 / SOD2等）、EMT及细胞骨架的关系；检测并分析不同转移能力的舌鳞癌细胞株力学性能的差异；并研究改变侵袭转移相关基因、EMT及细胞骨架对力学性能及侵袭转移能力的影响。本研究即将阐明舌鳞癌侵袭转移的机理：即异常表达的侵袭转移相关基因通过诱导EMT、改变细胞骨架结构，最终导致细胞力学性能的改变以及侵袭转移的发生，由此可见力学性能在舌鳞癌的侵袭转移中起重要作用，有望成为舌鳞癌的分子标志物，在舌鳞癌的诊断、预后预测以及分子治疗靶点中具有重要的应用价值。

In our previous studies we had found that the metastasis of tongue squamous cell carcinoma (TSCC) is related to the deregulation of multiple genes,such as miR-138、SOD2, epithelial-mesenchymal transition (EMT) and biomechanical properties. In order to further study the relationship between biomechanical properties and the metastatic potentiality of tongue squamous cell carcinoma, first we detect and analyse biomechanical properties (elastic modulus) in TSCC patients with or without lymph node metastasis and the relationship between biomechanical properties with metastasis related gene (miR-138 / SOD2 and so on)、EMT and cytoskeleton; Then we detect and analyse the biomechanical properties in TSCC cell lins with different metastatic potentiality and the change of biomechanical properties and metastasis of TSCC after revised the metastasis related gene、EMT and cytoskeleton. In our study we will clarify the molecular mechanism of how biomechanical properties mediated the metasistasis of TSCC; biomechanical properties , as a potentially biomarker, will have high value in the diagnosis, prognosis prediction and target treatment in TSCC.