目前人们越来越重视不良的生活习惯与疾病的关系。不良的饮食习惯可诱发许多生活方式疾病。其中，摄入过多盐与高血压、心脏病等疾病的发生有直接关系，近年来，流病调查显示，高盐饮食可能与缺血性脑血管疾病（ICVD）的发病有关，但是，国内外尚无直接实验数据表明高盐饮食与ICVD的关系，此外，其机制尚无人探讨。我们前期工作发现：高盐饮食诱发脑缺血损伤加重，可能与高盐饮食加重血脑屏障破坏、内源性小胶质细胞活化和外源性炎性细胞浸润增多有关，相关研究未见报道。本课题以实验动物为研究对象，结合临床资料，通过细胞、分子、蛋白水平，证实高盐饮食对脑缺血损伤的影响；阐明高盐饮食加重脑缺血损伤过程中血脑屏障破坏机制；明确高盐饮食脑缺血损伤过程中炎性细胞参与机制；探讨高盐饮食抑制脑缺血后血管重塑机制。阐明这些问题，将不仅丰富脑缺血发病机制的理论，而且为脑缺血的防治提供理论依据，为人们健康饮食提供科学指导。

Nowadays people pay increasing attentions on the relationship between bad life style and diseases. Poor diet habit may induce many lifestyle related diseases. Excessive intake of salt has a direct relationship with high blood pressure, heart diseases and other diseases. High salt diet which is one of the most possibly factors causing the formation of cerebral infarction according to the epidemiologic surveys in recent years, and may be associated with ischemic cerebrovascular disease (ICVD) pathogenesis. However, no direct experimental data have clarified the explicit mechanism. Our previous work found that: High salt diet induced cerebral ischemic injury aggravation, and this result may have a connection with blood-brain barrier damage, endogenous microglial activation and inflammatory cell infiltration which has not been reported or mentioned. We use experimental animals combined with clinical data for this study, and also use cellular, molecular, protein methods to confirm the influence of high salt diet on cerebral ischemic injury; to clarify the process of high salt diet aggravating cerebral ischemia BBB mechanism; to clarify the participatory mechanisms of inflammatory cells during the process of high salt diet induced cerebral ischemia; explore the mechanisms vascular remodeling after high salt diet cerebral ischemic. To solve these problems, not only would enrich the theory of cerebral ischemia pathogenesis, but also provide a theoretical basis for the prevention and treatment of cerebral ischemia, and scientific guidance for people's health and diet.