我们前期研究发现新疆地区维吾尔、汉UC患者临床表型存在差异：维吾尔族患者为单一发病年龄高峰、发病年龄小、病情重、病变广泛、并发症发生率高、疗效差、复发率高，且HLA-DRB1、FUT2和IL-23R基因多态性与UC发病存在民族差异性。本研究首先利用宏基因组和代谢组学技术，寻找肠道菌群和粪便代谢物在维、汉UC患者中的差异，分析差异相关的代谢通路，阐明肠道菌群与维、汉UC发生及临床表型的关系。随后用具代表性的差异样本制备粪菌液，对UC大鼠及正常大鼠进行粪菌移植，取结肠粘膜组织，检测UC相关细胞因子的表达，观察差异菌对大鼠肠粘膜炎症反应的影响；并以差异代谢产物控制培养条件，培养UC大鼠及正常大鼠肠粘膜上皮细胞，检测UC相关细胞因子表达，观察差异代谢物对大鼠肠粘膜上皮细胞炎症反应的影响，进而验证维、汉UC患者不同肠道菌群和粪便代谢物对UC发生的影响，阐明肠道菌群在新疆维、汉UC发生、发展中的意义。

This study is based on the past, we have been found in Xinjiang Uygur and Han ulcerative colitis in patients with clinical phenotype differences：Uygur patients with a single age peak of onset and the age of onset is small, the disease is serious, the disease is widespread, the complication is high, the effect is poor, the recurrence rate is high, And HLA-DRB1, FUT2 and IL-23R gene polymorphisms were different in the incidence of ulcerative colitis between the two ethnic groups.First,This distinguish used macrogeome and metabolomics to study the differences between the intestinal flora and fecal metabolites between Xinjiang Uygur ethnic group and Han groups, and further analyzed the correspondence between them. To understand the possible metabolic pathways associated with this difference. After wards,the gut microbiota of UC model rats and normal rats should be manipulated via fecal microbiota transplantation with representative samples, and then to detect the expression of cytokines in colonic mucosa. In order to observe the effect of different bacteria on intestinal mucosal inflammation in rats.The medium conditions is Controlled by significant differences in metabolites,we should cultivate the mucosal epithelial cells of UC model rats and normal rat intestinal , and the expression of cytokines in colonic mucosa will also be detected to observe the effect of different metabolites on the inflammatory response of intestinal epithelial cells in rats.In order to verify the effects of different intestinal flora and fecal metabolites on the occurrence of UC in patients with UC, and to elucidate the significance of intestinal flora in the occurrence and development of UC in Uygur and Han nationalities in Xinjiang.