目前艾滋病已被公认为是一种慢性疾病，我国HIV/AIDS患者总量逐年递增，需要长期的慢性病自我管理，提高患者健康水平和预防HIV二代传播。但是我国缺乏对HIV/AIDS患者进行自我管理的研究，而且现有医疗体系也缺乏提供传统自我管理服务的资源。本研究适应我国手机日益普及的国情，首次创新性的利用和开发移动技术（手机、应用程序和信息平台，mHealth），借鉴国内外成功的慢性病自我管理经验，探索利用mHealth为HIV/AIDS患者提供个性化自我管理服务的可行性和有效性。本研究以社会认知和社会生态学理论为指导，结合定性访谈和重复测量随机对照干预试验的研究方法，对个人和社会层面影响HIV治疗行为和健康结局的关键因素（HIV相关知识、自我效能、社会支持）进行针对性的干预，改善患者HIV治疗行为和提高健康水平。研究结果对中国HIV治疗、公共卫生管理和政策制定都具有重要的理论和实践意义。

Human Immunodeficiency Virus (HIV) has been widely recognized as a chronic disease. The number of people living with HIV/AIDS (PLWHA) has been increasing over the years in China. There is a great need for PLWHA to have self-management program to improve their health outcomes and to prevent HIV transmission. However, there is a lack of research on self-management among PLWHA in China and the existing health infrastructure is in shortage of necessary resources to provide traditional self-management services for PLWHA. Based on international and domestic evidence-based successful self-management experiences and situated in China with widely usage of mobile phone, the current study is the first effort to innovatively employ mobile technology and develop mobile app and information platform (mHealth) to explore the feasibility and efficacy of using mHealth to provide patient-centered individualized self-management services for PLWHA. Guided by social cognitive theory and social ecological theory, the current study will use mixed methods of both in-depth interviews and randomized controlled trial (RCT) with repeated measurements. Key individual and social factors that have significant impact on patients’ HIV treatment-related behavior and health outcomes are identified, including HIV-related knowledge, self-efficacy and social support, and corresponding intervention strategies are developed for the purposes of improving patients’ HIV treatment-related behavior and health outcomes. Findings of this study will have important theoretical and practical implications for HIV treatment, public health, health management and policy making in China.