经颅聚焦超声介导载天麻素脂质微泡对帕金森病靶向调控机制的研究

帕金森病是继阿尔兹海默病之后全球最常见的老年性神经退行性疾病，其发病率随着年龄的增加不断增高，有效地治疗帕金森病具有重要的社会经济价值。目前，治疗帕金森病的主要手段是药物干预，但存在明显的副作用，且不能阻止病情进展。相关研究表明,氧化应激与帕金森病高度相关。云南天然药天麻素显示有良好的抗氧化和神经保护作用，但其为水溶性药物，难以大量透过血脑屏障。聚焦超声联合微泡载药技术为打开血脑屏障靶向递药提供了可能。本研究通过经颅聚焦超声介导载天麻素脂质微泡定向爆破技术研究其导致血脑屏障开放的机制及其对帕金森病靶向调控的机制。为临床中枢神经系统疾病用药提供一种有效可靠的技术手段和理论依据，为云南天然药物寻求可能的增效治疗途径。

Parkinson’s disease (PD) is the most common neurodegenerative disorder after Alzheimer’s disease. The incidence of Parkinson's disease increases with age. Effective treatments of PD are of great socioeconomic importance. The main treatment for PD today is drug intervention, which has serious side effects and cannot prevent the disease progression. Studies have shown that oxidative stress is highly correlated with PD. Although Gastrodin has been proved to generate beneficial anti-oxidation and neuroprotective effects, it is difficult for Gastrodin to pass through the blood-brain barrier (BBB) in large quantities because of its water solubility. The technology-Focused Ultrasound (FUS) mediated drug-loaded microbubbles makes targeted drug delivery possible by opening BBB. In this study, the technology- Transcranial FUS mediated Gastrodin-loaded lipid microbubble destruction was used to explore the mechanism of BBB opening and the mechanism of its targeted regulation in PD. It will provide an effective and reliable approach and theory for the drug administration route of central nervous system diseases, as well as possible therapeutic approach to enhance the effect of Yunnan natural medicine.