阻塞性睡眠呼吸暂停低通气综合征可引起间歇性缺氧及氧化应激反应，进一步可导致动脉粥样硬化等心血管疾病。近期研究发现分泌性卷曲相关蛋白5（SFRP5）与动脉粥样硬化关系密切，我们前期研究发现阻塞性睡眠呼吸暂停低通气综合征患者分泌性卷曲相关蛋白5下降，颈动脉内膜中层厚度增加，推测间歇性缺氧可能影响SFRP5的分泌和功能，进而通过Wnt信号通路导致动脉粥样硬化的发生。本课题拟通过临床病例对照研究、间歇性缺氧细胞培养及建立间歇性缺氧SFRP5基因敲除动物模型，研究间歇性缺氧对SFRP5分泌及功能的影响，明确SFRP5在间歇性缺氧导致动脉粥样硬化机制中的作用。

Obstructive sleep apnea hypopnea syndrome can cause intermittent hypoxia and oxidative stress, which can further lead to cardiovascular diseases such as atherosclerosis. Recent studies have found that secretory frizzled-related protein 5 (SFRP5) is closely related to atherosclerosis. Our previous study found that patients with obstructive sleep apnea hypopnea syndrome have a decrease in secretory frizzled-related protein 5 and an increase in carotid intima-media thickness. It is speculated that intermittent hypoxia may affect the secretion and function of SFRP5, which leads to the occurrence of atherosclerosis through the Wnt signaling pathway. This study intends to study the effects of intermittent hypoxia on the secretion and function of SFRP5 through clinical case-control study, intermittent hypoxic cell culture and establishment of an intermittent hypoxia animal model with SFRP5 gene knockout, and to identify the role of SFRP5 in the mechanism of intermittent hypoxia-induced atherosclerosis.