青少年暴力犯罪已成为严重的社会问题。我们前期研究表明，被羁押的青少年中近80%符合品行障碍的诊断，且存在冲动性高、神经影像学异常等脑发育缺陷线索。近年来全基因组关联分析发现并经验证，与神经发育密切相关的Robo2基因为品行障碍重要的候选基因。我们假设青少年品行障碍暴力犯罪者存在脑神经网络发育缺陷且可能与Robo2基因多态性相关联，故拟以15-16岁男性青少年品行障碍暴力犯罪个体为研究对象，采用分子遗传学、多模态磁共振及神经心理学评估等技术，将Robo2基因多态性与其神经心理学特征和多模态脑神经发育影像学模型进行关联性分析。以期从分子遗传学-脑神经网络-临床心理特征水平，建立以循症医学为基础的、从宏观到微观、多模态脑神经发育预测、评估模型，探索其神经病理生理机制，为寻觅有效预防青少年暴力犯罪及有针对性的、多层次的个体化生物学干预提供有重要价值的科学信息。

Adolescent violent crime is becoming a serious social problem. Our previous study found that more than 80% adolescent offenders meet the conduct disorder criterion. Thus, this proposal will focus on the 15-16 year old male adolescent violent offenders with conduct disorders. The molecular genetics, multi-modal MRI (whole brain volume and cortical thickness, resting-state networks, and DTI) and neuropsychological assessment technologies will be used. We propose to test the hypothesis that the neuro-development candidate gene (Robo2) would associated with the maldevelopment of brain of violent offenders with conduct disorders, which would be detect by using the neuro-imaging studies. The polymorphism of Robo2 gene, which was found as a candidate gene in a recent genome-wide association study, was also found to be associated with the conduct disorders in a western study. This proposal is important not only for the understanding of the structural and functional brain circuits development which might lead to the violent crime, but also for the understanding of the neurobiological mechanisms of the violent behaviors, and will provide the important biological informations for effective prediction, prevention and intervention for the youth violent offenders.