医疗器械和植入物沾染细菌危及患者生命。手性生物界面有可能从源头上阻止细菌黏附和繁殖，对研发新型医用抗菌材料、减少医院内细菌感染具有重大意义。本项目拟利用界面手性作用，以设计合成的多种新型龙脑基手性高分子膜为界面模型，研究界面手性与抗菌性的构效关系，探索高分子的手性功能放大及生理活性变化，从而揭示高分子界面手性抗菌的本质。该类材料不仅可以利用龙脑高分子的界面手性作用，从源头上阻止细菌黏附，达到抗菌目的；还可以利用龙脑本身的杀菌能力，保证这种手性高分子界面的长效抗菌能力，实现强化抗菌的效果。本项目希望通过在界面上有机结合天然手性药物和生物相容性高分子材料的优势，为手性抗菌和生物界面的研究和应用提供一类生物相容性好、稳定长效、不易产生抗药性且环境友好的新型生物材料。

Attachment of viable bacteria to medical devices and implants endangers human life. Chiral biointerface may have the effectiveness of resisting bacterial adhesion and propagation from the initial stage, which is of great significance for the research of novel antibacterial medical material and further to lessen the chance of nosocomial acquired infection. In this proposal, we propose the study of the structure-activity relationship between the interfacial chiralities and their antibacterial properties by using the concept of interfacial chiral effect with some new chiral films of borneol-based macromolecules, designed and synthesized by us, as the interfacial models. Through exploring the change of physiological activity and the enhanced chiral function after forming polymers on the surface, the hypostasis of the antibacterial property owned by the chiral effect of macromolecular interface is revealed. These materials not only can employ the interfacial chiral effect of borneol-based macromolecules to resist the adhesion of bacteria from the initial stage thus realizing an antibacterial aim, but also may utilize the bactericidal ability of borneol itself to ensure the long-term antibacterial property on the chiral macromolecular interface, which can enhance and prolong the antibacterial effectiveness on the interface. It is expected that through organically combining the advantages of both chiral drugs from natural sources and biocompatible macromolecules in this proposal, a novel sort of chiral antibacterial biomaterial and chiral biointerface, which may have many advantages such as biocompatible, stable, long-term effectiveness, environment-friendly and no drug-resistance, will be supplied for both research and application in the related fields.