神经源性膀胱过度活动症（OAB）是泌尿外科、神经科等学科共同面对的难题，中国脑血管病患者数目庞大，其导致的神经源性OAB的发生率正日益增高，但其发生机制尚不清楚。神经源性OAB的研究过去主要集中在下尿路和脊髓，对于大脑对膀胱的控制研究很少；然而大脑-膀胱控制对人类正常排尿起着关键作用。近年来随着脑影像技术的迅速发展，静息态功能磁共振成像技术（rs-fMRI）及其分析方法成为人类揭开大脑之谜所必需依赖的尖端技术。本课题旨在运用rs-fMRI技术，采用局部一致性、低频振幅、功能连接、小世界属性、脑网络连结的先进分析方法，选择额叶脑梗塞导致OAB患者为观察对象，设立健康人及额叶脑梗塞排尿正常者两个对照组，精确定位导致神经源性OAB的具体额叶区域，识别评估额叶病变对控尿相关其它大脑区域功能的影响，发现识别神经源性OAB的特异性脑网络连接模型，为神经源性OAB的防治提供科学依据。

Neurogenic overactivity bladder (OAB) is a refractory disease in Urology and Neurology. In china, the number of patients with cerebral vascular diseases (CVA) is huge, the percentage of neurogenic OAB caused by CVA was increasing in recent years; however, the pathological mechanism of neurogenic OAB was not clear. Most of studies on neurogenic OAB mainly concentrated in the lower urinary tract and spinal cord, and few studies focused on brain-bladder control; but the brain control on the bladder plays a key role in normal micturition in human being. With the rapid development of brain imaging technology, resting state functional magnetic resonance imaging (rs-fMRI) and the analysis methods of rs-fMRI have become the indispensable sophisticated technologies that are used by the human being to uncover the riddle of brain. The rs-fMRI and the analysis methods, e.g. REHO, ALFF, FC, SMALL WORLD, NETWORK will be used in this study. The patients of neurogenic OAB caused by frontal cerebral infarction will be included as the observation subjects, the normal volunteers and the CVA patients with normal voiding will be included as two control groups. The purposes of this study are to locate accurately the specific frontal cortex region causing neurogenic OAB, to recognize and evaluate the functional changes of other brain areas surrounding frontal cortex region, to find and evaluate the specific brain network connection models of neurogenic OAB. Finally, the scientific basis for the prevention and treatment for neurogenic OAB will be provided.