传统的自由基反应一般采用卤代物或特殊的活性前体，在引发剂或光辐射条件下发生。采用非卤代的底物和非经典的引发体系，能够大大扩展自由基反应的适用范围，弥补现有方法存在的不足。最近,我们发现t-BuOK/DMF有效促进α-芳基叔胺与烯烃和酮的分子内环化反应，以良好的产率制备了四氢喹啉和2-芳基吲哚类产物。多项实验证据表明反应中t-BuOK/DMF产生氨基甲酰自由基，然后夺取叔胺α-位氢原子，形成α－胺基烷基自由基并发生后续反应。在此基础上，我们希望对t-BuOK/DMF体系中自由基形成机理和反应途径开展深入研究，发展t-BuOK/DMF及相关体系促进的α-芳基叔胺、α-芳基醚、叔烷烃、二芳基甲烷、（氮、氧、硫）缩醛等与烯烃、炔烃、酮、亚胺、芳基卤、缺电子芳烃之间的新型自由基加成和偶联反应。此外，也研究t-BuOK/DMF及相关体系产生的氨基甲酰基自由基与多种底物之间的氨基甲酰化新反应。

Free radical reactions are typically carried out with halogenated substrates or special precursors in the presence of initiators or under light irradiation. New free radical reactions using non-halogenated substrates and non-classical initiation systems are highly desirable in terms of the application scope and disadvantages of present methods. Recently, we found that the intramolecular cyclizations of α-aryl tertiary amines with alkenes or ketones are efficiently promoted by t-BuOK/DMF. Tetrahydrogenquinolines and 2-aryl-indoles were prepared in good yields. A number of experiment evidences strongly suggest the generation of the carbamoyl radical from t-BuOK/DMF system. The carbamoyl radical abstracts a hydrogen from the tertiary amine to provide the α-amino alkyl radical, which initiates the consequent cyclization. Based on the new finding, we will study the generation mechanism of free radical intermediates and subsequent reaction pathways in t-BuOK/DMF system. We will also explore new free radical additions and couplings of α-aryl tertiary amines, α-aryl ethers, tertiary alkanes, diaryl methanes, acetals with alkenes, alkynes, ketones, imines, aryl halides, and electron-deficient arenes in t-BuOK/DMF and the related systems. In addition, we will study new carbamoylation reactions based on the reactivity of the carbamoyl radicals generated in t-BuOK/DMF and the related systems.