烯基硫鎓盐是一种具有独特结构和反应性能的Michael受体。在与亲核试剂反应后，形成的硫叶立德中间体既可以作为亲核试剂进攻羰基、亚胺和其它Michael受体，得到三元环状化合物。也可以作为一种强碱，从分子内含活泼氢的基团（如羧基、羟基、酰胺、活性亚甲基等）夺取质子，得到的硫鎓盐继续发生SN2反应，产生各种环系产物。这些丰富多变的反应性能对于有机合成具有很高的价值。虽然文献中对烯基硫鎓盐参与的几类反应已经有所报道，但手性催化剂促进的不对称反应至今未有研究。基于我们在不对称催化反应领域的研究经验，以及对烯基硫鎓盐的合成及催化不对称反应的前期研究结果，我们计划针对烯基硫鎓盐的结构特点，采用手性离子对、负离子-氢键作用、相转移催化几种模式，发展烯基硫鎓盐的一系列催化不对称串联反应，为多类结构独特的手性杂环和碳环化合物的制备提供新方法，并探索新反应在药物和天然产物合成中的应用价值。

Vinyl sulfonium salts are a kind of Michael acceptors with special structure and reactivities. After the reaction with nucleophiles, the resulting sulfur ylides can attack carbonyls, imines and other Michael acceptors to generate the products with three-member rings. On the other hand, the sulfur ylides can also work as strong bases to abstract a proton from carboxylic acids, hydroxyls, amides and activated methylene groups. The subsequent SN2 reaction provides various cyclic products. The diversified reactivities of vinyl sulfonium salts are highly valuable for organic synthesis. Although a number of reactions of vinyl sulfonium salts were reported in the literatures, the catalytic asymmetric reactions have never been developed. Based on our research experiences and the preliminary results on the synthesis and catalytic asymmetric transformations of vinyl sulfonium salts, we hope to develop a series of new asymmetric cascade reactions. Considering the special structure of vinyl sulfonium salts, the catalytic modes of chiral ion pair, anion H-bonding, and phase-transfer will be applied. The new reactions are expected to provide efficient synthetic approaches to a variety of chiral heterocyclic and carbocyclic products. In addition, the applications of the new reactions to the preparation of chiral drugs and natural products will also be explored.