甲状腺癌是最常见的内分泌恶性肿瘤。虽然整体预后良好，但肿瘤转移后仍没有有效的治疗手段。研究已证实，长链非编码RNA （lncRNAs）在多种肿瘤组织中表达异常，并发挥着原癌基因或肿瘤抑制基因的活性。最新研究证实，LINC-PINT在某些类型的肿瘤中具有重要的调控功能，但LINC-PINT在甲状腺癌中的功能尚不明确。我们发现甲状腺癌组织LINC-PINT的表达水平显著下降，并且与TNM分期和淋巴结转移显著相关。初步机制研究发现，LINC-PINT可能通过miR-767-5p/TET2轴调控了甲状腺癌的功能。本项目拟在分子、细胞和动物水平，研究LINC-PINT对甲状腺癌细胞的调控功能机制，在人群样本水平，分析LINC-PINT及下游靶分子在临床甲状腺癌病人样本中的表达关联性及与病人病理参数之间的相关性。为甲状腺癌的发生发展提供新的理论机制，为甲状腺癌的临床诊断、治疗以及预后分析提供新思路。

Thyroid cancer is one of the most common endocrine malignancies. Although the overall prognosis is good, there is still no effective treatment after tumor metastasis. Many studies confirm that long-chain non-coding RNAs (lncRNAs) are abnormally expressed in various tumor tissues and exert the activity of oncogenes or tumor suppressor genes. Recent studies have confirmed that LINC-PINT plays important roles in many types of tumors. However, the function of LINC-PINT in thyroid cancer is still not clear. Our primary data show that the expression level of LINC-PINT is decreased in thyroid carcinoma tissue, and that low expression of LINC-PINT in thyroid cancer is significantly associated with later TNM staging and lymph node metastasis.The preliminary mechanistic studies indicate LINC-PINT may regulate the function of thyroid cancer through the miR-767-5p / TET2 axis. In this project, we will study the mechanism of LINC-PINT in regulating thyroid cancer at molecular, cellular and animal levels. Besides, we will investigate the expression correlation between LINC-PINT and its downstream targets. We will analyze if the expression levels of LINC-PINT and its downstream targets is correlated with pathological parameters in clinical thyroid cancer patients. Our study will reveal novel mechanism that regulating thyroid cancer and provides new targets and ideas for clinical diagnosis, treatment and prognosis analysis of thyroid cancer.