先天性脊柱侧凸(CS)的诊治是脊柱外科的难题，其发生除与遗传因素相关外,表观遗传的改变也发挥重要作用，但具体机制尚不明确。环状RNAs(circRNAs)是一类新发现的呈环状的非编码RNA分子，circRNAs在疾病的发生、发展中发挥着重要的调控作用。前期的研究中，我们对一位CS患者和另一位正常对照进行外周血circRNAs测序，结果显示CS与对照间存在差异表达的circRNAs。据此推测，外周血circRNAs可能与CS的发生密切相关。在此基础上，本课题将应用circRNAs测序、qRT-PCR在更多样本中考察circRNAs的表达差异，进一步在细胞水平进行circRNAs的表达调控和功能研究，揭示circRNAs与CS发生发展的关系，筛选出与CS发生相关的circRNAs。目前国内外尚未见circRNAs在CS的研究报道，本研究将为CS的预防、早期诊治提供新的思路和新的靶点。

The diagnosis and treatment of congenital scoliosis (CS) is a challenge in spine surgery. In addition to genetic factors, epigenetic changes also play a significant role in the pathogenesis of CS. Circular RNAs (circRNAs) is a group of novel non-coding RNAs. Increasing studies show that circRNAs are involved in the regulation of many human diseases. Our previous study performed peripheral blood circRNAs sequencing and showed differential circRNA expression between the peripheral blood of CS patients and the healthy control. Therefore, we speculated that circRNAs may play a role in the pathogenesis of CS. Based on our previous findings, we will analyze the expression of circRNA in more samples using circRNAs sequencing and qRT-PCR. In addition, we will study the expression and function of circRNA in vitro to investigate the role of circRNA in the development of CS. As far as we know, there is no report on the research of circRNAs in CS. This study may provide novel new targets for the prevention, early diagnosis and treatment of CS.