斜视是由于眼球位置或运动异常所引起的双眼视轴分离，是儿童常见眼病之一，人群中患病率约1%~4%，其中共同性斜视（Comitant strabismus, CS）是最常见的类型。斜视不仅有碍外观，且由于眼位偏斜带来复视和混淆视，产生单眼抑制和视网膜异常对应，导致纹状皮层中双眼视觉细胞明显减少，从而严重影响双眼视觉功能。CS具有高度遗传及临床异质性，能够以一种复杂遗传性状向后代传递，家系研究提示遗传因素在其发病机制中具有非常重要的作用。本课题通过对CS家系及散发人群进行基于NGS的遗传关联研究，进而鉴定影响眼球运动发育的重要功能位点及基因，有助于阐明斜视发生的分子遗传机制，同时结合流行病学研究，最终可为CS的预防和个性化治疗提供基础。

Strabismus is a condition in any misalignment of the eyes in coordination between the extraocular muscles, adversely affecting the binocularity, stereopsis, and depth of perception. Combatant strabismus (CS) is the most type of strabismus, which affects normal binocular vision function even in the absence of amblyopia, subsequently affecting daily physiological and psychosocial performance unless successfully treated. At present, the reason for the development of CS is unclear, although various hypotheses causing its occurrence have been proposed. CS has a high degree of genetic and clinical heterogeneity, with a complex genetic traits to their offspring, family studies suggest that genetic factors play an important role in the pathogenesis of CS. This study focuses in genetic linkage analysis for CS in the Chinese population。To identify the important loci and genes which would affect the development of eye movements, and elucidate the molecular genetic mechanism of strabismus.