人粒细胞无形体病是由嗜吞噬细胞无形体引起的经蜱传播的虫媒传染病。近年来,在美国、欧洲、东南亚、非洲等地流行,我国曾在黑龙江、内蒙古和新疆等地的全沟硬蜱中检测到嗜吞噬细胞无形体，在安徽首先发现患者，随后在山东、河南也发现该病流行。该病主要引起发热,严重者可引起多脏器损害,甚至死亡，因此日益受到国内外的关注与重视。目前我国西南地区的无形体病研究不够充分。我们的初步研究表明，云南人群中嗜吞噬细胞无形体感染率较高，因此，加强云南及周边地区人粒细胞无形体病的研究具有重要意义。本项目拟在云南的从滇中、滇西、滇南、滇东、滇西北选择现场，系统地开展人、家畜、野生动物和媒介硬蜱嗜吞噬细胞无形体感染的血清流行病学、分子流行病学和病原体分离鉴定研究，探索云南省人粒细胞无形体病的流行特征和病原体特征，未雨绸缪，做好前瞻性基础研究，为云南省及周边地区人粒细胞无形体病防控提供科学基础和策略。

Human granulocytic anaplasmosis is the tick-borne infectious disease caused by Anaplasma phagocytophilum. In recent years, this disease is endemic in the United States, Europe, Southeast Asia, Africa. Anaplasma phagocytophilum genes has been identified positively in Ixodes persulcatus rom Heilongjiang, Inner Mongolia and Xinjiang and other places in China. Human granulocytic anaplasmosis cases of China were first found in Anhui, then found epidemic in Shandong, Henan Province. The main symptoms of the disease are fever, anaemia and leukopenia. severe cases can lead to multiple organ damage, and even death. So this disease is being paid more and more attention in the world. The anaplasmosis in southwest China has still not been well investigated. Yunnan is a high incidence area of vector-borne rickettsiosis, therefore, to strengthen the study of human granulocytic anaplasmosis in Yunnan and the surrounding areas is of great significance. The project will select research fields from central Yunnan, western Yunnan, southern Yunnan, eastern Yunnan, and Northwest Yunnan, systematically carry out the study on serum epidemiology, molecular epidemiology, pathogen isolation and identification of Anaplasma phagocytophilum infections in people, livestock, wild animal and tick population，and expore the epidemiological characteristics and the pathogenic characteristics of human granulocytic anaplasmosis in Yunnan Province. The final goal of this project is to implement a propectively proactive research work to provide scientific basis and strategies for human granulocytic anaplasmosis prevention and control in Yunnan province and the surrounding areas.