基于7T超高场磁共振的同时多层采集和超分辨重建的颅内动脉粥样硬化斑块成像方法研究
结题报告
批准号:
82001804
项目类别:
青年科学基金项目
资助金额:
24.0 万元
负责人:
张紫豪
学科分类:
磁共振成像
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
张紫豪
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中文摘要
卒中已成为我国人口致死致残的首要病因,而颅内动脉粥样硬化(ICAS)为我国缺血性卒中的最主要原因。分辨ICAS斑块的成分对于评估斑块稳定性和确定治疗方案具有重要意义。但由于ICAS斑块尺寸较小,受限于已有成像技术的分辨率、对比度和采集时间等多方面因素,一直以来缺少能可靠分辨ICAS斑块成分的影像技术。我们的前期工作发现,7T超高场磁共振下的二维管壁成像序列可提供斑块截面的高对比度清晰影像,据此提出通过加速采集和三维重建,可获得能够分辨ICAS斑块成分的三维高分辨率高对比度管壁影像。本研究将采用同时多层采集技术加速7T下的二维高对比度管壁成像序列,以斑块区域的正交二维影像为输入,通过超分辨率重建算法获得斑块的三维高分辨率影像。本项目拟实现10分钟扫描获得斑块区域各向0.20mm的高对比度影像,清晰显示ICAS斑块成分,为颅内斑块的分析和ICAS的诊断与研究提供关键的影像资料。
英文摘要
Identifying the components of intracranial atherosclerotic (ICAS) plaques is of vital importance in evaluating the stability plaques and determining treatment plans. However, considering the small size of ICAS plaques, there is no imaging technique that can reliably display the components of ICAS plaques. The limiting factors of currently available imaging techniques are spatial resolution, contrast, and acquisition time. Our preliminary work found that the 2D vessel wall imaging sequence at 7T ultra-high field magnetic resonance can provide high-contrast and delicate images on the cross sections of plaques. Based on the result, we propose that by exploiting accelerated acquisition and three-dimensional reconstruction, it is possible to obtain 3D high-resolution high-contrast vessel wall images, which can clearly depict the components of ICAS plaque. In this study, simultaneous multi-slice acquisition will be used to accelerate the 2D high-contrast vessel wall imaging sequence at 7T. Using orthogonal 2D images of the plaques as input, a 3D high-resolution image of the plaque will be generated via a super-resolution reconstruction algorithm. This project aims to obtain a high-contrast image of ICAS plaque with isotropic 0.20mm resolution in 10 minutes. The final images will delineate the composition of ICAS plaques, which is crucial in analysis of intracranial plaque, and will aid the diagnosis and research of ICAS.
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DOI:10.1007/s00330-023-09652-7
发表时间:2023-04
期刊:European Radiology
影响因子:5.9
作者:Chen Ling;Jinyuan Zhang;Xingfeng Shao;Li Bai;Zhixin Li;Yunchuang Sun;Fan Li;Zhaoxia Wang
通讯作者:Chen Ling;Jinyuan Zhang;Xingfeng Shao;Li Bai;Zhixin Li;Yunchuang Sun;Fan Li;Zhaoxia Wang
DOI:http://doi.org/10.1136/neurintsurg-2021-017688
发表时间:2021
期刊:Journal of NeuroInterventional Surgery
影响因子:4.8
作者:Xinke Liu;Junqiang Feng;Zhixin Li;Zihao Zhang;Qaing Zhang;Yuhua Jiang;Xiaochuan Huo;Xubin Chai;Yue Wu;Qingle Kong;Peng Liu;Huijian Ge;Hengwei Jin;Jing An;Peng Jiang;David A Saloner;Youxiang Li;Chengcheng Zhu
通讯作者:Chengcheng Zhu
DOI:10.3389/fneur.2021.700476
发表时间:2021
期刊:Frontiers in neurology
影响因子:3.4
作者:Wei N;Zhang X;An J;Zhuo Y;Zhang Z
通讯作者:Zhang Z
DOI:10.3389/fnins.2021.620172
发表时间:2021
期刊:Frontiers in neuroscience
影响因子:4.3
作者:Kong Q;Wu Y;Weng D;An J;Zhuo Y;Zhang Z
通讯作者:Zhang Z
DOI:10.3389/fneur.2022.944863
发表时间:2022
期刊:FRONTIERS IN NEUROLOGY
影响因子:3.4
作者:Wei, Ning;Jing, Jing;Zhuo, Yan;Zhang, Zihao
通讯作者:Zhang, Zihao
基于超高场磁共振的脑小血管结构与功能一体化高时空分辨率成像方法研究
国内基金
海外基金