淀粉样β蛋白（Aβ）在脑内的纤维化聚集是导致阿尔茨海默病（AD）的主要原因，因此抑制Aβ聚集和降解Aβ聚集体是防治AD的主要策略。本项目提出了基于介尺度科学研究Aβ聚集及其抑制反应过程、实现利用抑制剂修饰的纳米马达（I-NM）调控Aβ聚集和强化解聚反应的研究构想。围绕介尺度科学问题，将首先研究Aβ聚集及其抑制反应过程中的结构多样性，确定关键介尺度结构及其形成机制；然后研究Aβ聚集及其抑制反应过程中的关键介尺度结构的相互转化及其调控参数，建立Aβ聚集及其抑制反应过程的介尺度动态模型；最后研究I-NM对关键介尺度结构及其动态行为的影响规律，解析抑制聚集和解聚反应过程的调控和强化机理，为I-NM的优化设计奠定理论基础。本项目将介尺度科学和过程强化有机结合，通过关键介尺度结构解析和调控，实现蛋白质聚集抑制和解聚反应过程的调控与强化。研究成果将开拓介尺度理论的新应用，建立过程强化的新方法。

Amyloid β-protein (Aβ) fibrillation is the main etiology of Alzheimer’s disease (AD), so inhibition of Aβ aggregation and disaggregation of Aβ aggregates is an effective strategy for the prevention and treatment of AD. In this project, we proposed to study Aβ aggregation and its inhibition based on the mesoscience, and to utilize inhibitor-modified nanomotors (I-NM) to regulate and intensify the aggregation inhibition and disaggregation. Focusing on the mesoscale scientific issues, the structural diversity in Aβ aggregates as well as the inhibition of aggregation will be investigated in the first place, identifying the key mesoscale structures and their formation mechanisms. Then, transitions of the key mesoscale structures and their regulation parameters will be studied to establish dynamic mesoscale models for the Aβ aggregation and its inhibition. Finally, the patterns of I-NM affecting the key mesoscale structures and their dynamic behaviors will be explored to analyze the mechanisms for the regulation and intensification on Aβ aggregation inhibition and disaggregation. This will theoretically benefit in the optimization design of I-NM. This project will thus realize the regulation and intensification of protein aggregation inhibition and disaggregation by integrating mesoscience with process intensification and by identifying and regulating the key mesoscale structures. The outcomes will provide new insights into the application of mesoscience, and establish new methodology for process intensification.