髓芯减压广泛应用于治疗早期股骨头坏死(ONFH)。临床发现该法对有的患者疗效明显，有的效果较差。ONFH是由动脉缺血和静脉回流障碍两种不同的血液循环障碍所引起。我们通过对两百例早期ONFH患者进行数字减影动脉造影术(DSA)检查，发现髓芯减压对静脉回流障碍的患者疗效明显，而对动脉缺血性的患者效果并不十分理想。本研究通过脂多糖(LPS)联合甲基强地松龙(MPS)，建立犬早期ONFH模型，行DSA将模型分为动脉缺血和静脉回流障碍两种类型。分别实施髓芯减压联合骨髓基质干细胞(BMSC)移植术及带血管蒂骨瓣移植。观察股骨头内血运重建及新骨生成情况，分子生物学检测血管内皮因子及骨形成蛋白-2基因在股骨头内的表达。探讨髓芯减压联合BMSC移植对动脉缺血和静脉回流障碍所致犬ONFH的修复作用的差别，为提高保头治疗成功率提出新的理论依据。

Core decompression is widely used in the treatment of early femoral head necrosis(ONFH).We found that some patients recovery well through core decompression, but some patients' conditions have progressed very quickly. ONFH can be caused by two different types of blood circulation disorders, arterial ischemia and venous congestion. We find that the rapeutic effect of core decompression is good for venous congestion ONFH, but not very good for arterial ischemic ONFH through digital subtraction angiography (DSA) of two hundred of early ONFH. In this study, we use lipopolysaccharide (LPS) combined with methylprednisolone (MPS) to imitate the clinical etiology and establish dogs early ONFH model. After that, DSA and anatomy further divide ONFH models into arterial ischemic ONFH and venous stasis ONFH. Two different operations are put for two types of blood circulation disorder models. One is core decompression combined with bone marrow stromal stem cells, the other one is autologous bone grafting with blood vessel pedicle. According to different time points after operations, we observe dynamic revascularization by magnetic resonance imaging (MRI) and X-ray. The formation of new bone was detected by histology. Moreover, DSA and anatomy display the femoral head revascularization. Molecular biology is used to detect vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) gene expression in vivo. We explore the repair disparity for the canine ONFH with different surgical operations due to arterial ischemia and venous congestion. This research will put forward a new theory in order to improve the success rate of the early ONFH treatment.