造血系统代谢失常或功能紊乱会引起白血病等血液系统肿瘤和自身免疫病的发生。因此，深入研究影响细胞免疫的基因的功能及作用机制，对揭示细胞免疫应答及血液系统肿瘤的形成具有重要意义。果蝇和人类存在许多高度保守的信号转导通路和转录因子调控血细胞的生长发育及功能。本研究利用jumu基因的多种转基因果蝇，采用免疫学、分子生物学、细胞生物学、遗传学等方法，明确jumu对浆细胞增殖和吞噬功能的影响；探索薄层细胞分化、黑色素瘤的产生、脂肪解体以及脂肪解体与细胞免疫应答的关系；揭示与调控细胞免疫应答的信号转导途径的相互关系；阐明jumu蛋白在细胞免疫中直接或间接调节的下游基因组；明确在转录过程中受jumu蛋白所直接调节的基因。此研究为进一步揭示jumu基因在细胞免疫中的功能及调控机理、发现调节细胞免疫的新的功能基因奠定理论基础。

Dysregulation of hematopoietic differentiation programme is at the origin of numerous pathologies, including leukaemias and autoimmune disease. Therefore, it is important to understand the function and regulatory mechanisms of novel genes in cellular immune responses. Many trancriptional regulators and signalling pathways involved in hematopoiesis are conserved between human and Drosophila，the fruit fly has become a good model for investigation the mechanisms underlying the generation of blood cell lineages and blood cell homeostasis. In order to understand the role of jumu in the cellular immune response,the jumu transgenic flies, and molecular biology, cell biology, genetics and immunological methods will be used in our experiment. In addition, functional analysis of transcription factor jumu in Drosophila cellular immune responses, including the plasmatocyte proliferation, phagocytosis, lamellocyte differentiation, melanotic tumor formation, and fat disintegration will be extensivly studied in third instar larvae; elucidate the relative role of cellular and humoral immune responses in Drosophila; demonstrate the cross talk between jumu and the hematopoietic transcriptional regulator; determinate the direct and indierect downstream target genes which were regulated by jumu in blood cell development. These results may lay the foundation for defining a new class of genes that are involved in cellular immune responses and hematopoietic disorders.