城市夜光对成人生育力的影响及其机制研究

地球夜光光污染问题正逐年加剧，鉴于生殖节律性的内分泌调控系统对光周期具有特别依赖作用，其对自然人群生育力的影响亟待评估。本研究将利用VIIRS/DNB夜光遥感数据，获取不同城市化水平和夜光强度的广东广州、广西南宁和新疆喀什地区不同日、月、年均光照数据，根据成人生育力流行病学调查获得的个体详细地址，精确定量约3万个体样本不同时间、空间梯度下的夜光暴露水平，与个体激素水平、生殖细胞活力等详细生育力检查指标建立相关关系，阐明夜光暴露对自然人群生育力的影响，及其影响是否存在性别差异。进一步通过对生物钟基因多态性人群的病例对照分析，评估夜光环境暴露与基因的交互作用对成人生育力的影响，阐明其潜在的可能机制，为政府制定光污染控制策略和采取针对性的干预措施提供科学依据。

The problem of light pollution on the earth's is increasing year by year. Since the reproductive rhythmic endocrine regulation system has a special dependence on the photoperiod, its impact on the fertility of the natural population needs to be evaluated urgently. This study will use VIIRS/DNB night-time remote sensing data to obtain the luminous intensity data of different day, month and year of Guangdong Guangzhou, Guangxi Nanning, and Xinjiang Kashi. According to the detailed address from epidemiological survey of adult fertility, accurate night-light exposure levels about 30,000 individual samples at different times and spatial gradients were quantified. Then by analyzing the association of exposure and individual hormone levels, reproductive cell vitality and other detailed fertility test index, clarify the effect of night-light exposure to the fertility of natural population, as well as whether there are gender differences in their effects. Through the subgroup analysis of light-sensitive gene population base on case-control study, we evaluated the interaction effect of night-light exposure and gene on adult fertility, clarified its potential mechanism. This study will provide scientific basis for the government to develop light pollution control strategies and take targeted interventions.