该项目基于量子点之间的激子耦合作用，结合可逆团聚的可控组装手段，通过表面修饰特异性识别分子以构建量子点可逆团聚荧光纳米探针，包括量子点团聚纳米探针和量子点可逆团聚开关纳米探针，以期实现生命体系中重要活性分子的高灵敏与特异性检测。该工作将发展量子点荧光传感的新原理与新方法，拓展量子点在化学生物传感领域的更深层次发展，同时也为量子点的功能纳米器件组装研究提供重要的参考价值。

In this project, a novel nanoprobe through reversible aggregation of quantum dots is established. The mechanism of this nanoprobe is based on exciton coupling accompanied by the aggregation of quantum dots. Both of the aggregation nanoprobe and disaggregation nanoprobe would be designed. This design has the advantage of versatile, sensitive, and specific detection for various biological biomolecular species, and would provide a novel means for nanoscopic sensing. We hope the concept and methodology developed in this project may be expanded for design of other nanoparticle sensors and functional nanodevices.