本项目拟在已合成的含分子阀门的介孔氧化硅基础上，设计合成一类新型的具有磁靶向和等离子体加热双效药物控释特性的介孔氧化硅复合材料；在这种材料的介孔内储存药物并通过智能分子阀门对药物进行靶向控释。项目研究包括：研究纳米Fe3O4和纳米贵金属M(Au,Ag)的相互作用，合成Fe3O4-M纳米颗粒并包覆介孔氧化硅，得到具有磁靶向及等离子体加热效应的双效介孔复合材料；筛选合适的有机硅烷，与具有生物兼容性的环形分子组建分子阀门，研究阀门的性质及对介孔孔口的修饰作用；研究药物在介孔复合材料体系中的储存、靶向可控释放及各种介质条件、分子结构等影响系统储存及可控释放的一般规律；通过对"储存-靶向-等离子体热控释体系"的表征，揭示其结构特征以及靶向热控释机理。本项目对于合成具有等离子体加热效应可控释放的磁靶向药物递送智能载体、认识介孔材料的储存特性以及分子阀门的结构与其性能之间的关系等，都具有十分重要的意义。

This project is to design and synthesize a new mechanized nanocontainer with the dual function of the magnetic-targeting and plasmonic-heating release of drugs. The nanocontainer is supposed to store drugs inside the mesopores, target with the magnetic power, and control its release by the featured 'intelligent nanovalves'. The nanocontainer is composed by the mesoporous silica nanopaticles(MSN), nanovalves and Fe3O4-M (M=Au,Ag). First, we study the effect of incorporating the superparamagnetic Fe3O4-M (M=Au,Ag) on the structure of MSN. Second, we screen the organosilanes and the biocompatible capping agents to constitute the optimal nanovalves. Third, we study the storage, target, controlled-release of drug in the nanocontainer under various operating conditions. Based on the above work, we will try to reveal the system mechanism from storage to targeting and plasmonic heating release of drugs in the nanocontainers. This project shed new insights into the design of the intelligent drug nanodevices, which will definitely be helpful to explore the applications by testing their delivery capabilities in different types of human cells.